Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors : A Population-Based Matched Cohort Study
© 2024 The Korean Academy of Medical Sciences..
BACKGROUND: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls.
METHODS: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls.
RESULTS: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54-1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81-2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17-2.92).
CONCLUSION: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of Korean medical science - 39(2024), 11 vom: 25. März, Seite e105 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Taehee [VerfasserIn] |
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| Links: |
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| Themen: |
Chronic Obstructive Pulmonary Disease |
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| Anmerkungen: |
Date Completed 27.03.2024 Date Revised 28.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3346/jkms.2024.39.e105 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Kim, Taehee |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors |b A Population-Based Matched Cohort Study |
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| 520 | |a © 2024 The Korean Academy of Medical Sciences. | ||
| 520 | |a BACKGROUND: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls | ||
| 520 | |a METHODS: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls | ||
| 520 | |a RESULTS: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54-1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81-2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17-2.92) | ||
| 520 | |a CONCLUSION: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chronic Obstructive Pulmonary Disease | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Pulmonary Tuberculosis | |
| 700 | 1 | |a Choi, Hayoung |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Sang Hyuk |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Bumhee |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Kyungdo |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Jin-Hyung |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Bo-Guen |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Dong Won |e verfasserin |4 aut | |
| 700 | 1 | |a Moon, Ji Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Sang-Heon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Tae-Hyung |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Ho Joo |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Dong Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Hyun |e verfasserin |4 aut | |
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