Are oral cancers effectively palliated with radiotherapy? Outcomes of treatment with a modified QUAD SHOT regimen
© 2024 Wiley Periodicals LLC..
BACKGROUND: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers.
METHODS: Retrospective data of 116 patients treated with a daily dose of 3.6-3.7 Gy in four fractions over 4 days to a total of three courses, with a 2-week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer.
RESULTS: Ninety-nine (85%) completed three courses. Overall subjective response rate was 77%. Median overall survival and progression-free survival were 12 months (95% confidence interval [CI]: 8-20) and 8 months (95% CI: 6-10), with numerically higher overall survival in oral cancer. The treatment was well tolerated, with no on-treatment hospitalization or grade 3-4 toxicities.
CONCLUSION: The modified QUAD SHOT regimen is practical for palliation in head and neck cancers.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Head & neck - (2024) vom: 25. März |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Saha, Saheli [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Advanced oral cancer |
|---|
| Anmerkungen: |
Date Revised 26.03.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1002/hed.27730 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370183266 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370183266 | ||
| 003 | DE-627 | ||
| 005 | 20240327000706.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240327s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/hed.27730 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1349.xml |
| 035 | |a (DE-627)NLM370183266 | ||
| 035 | |a (NLM)38528774 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Saha, Saheli |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Are oral cancers effectively palliated with radiotherapy? Outcomes of treatment with a modified QUAD SHOT regimen |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024 Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers | ||
| 520 | |a METHODS: Retrospective data of 116 patients treated with a daily dose of 3.6-3.7 Gy in four fractions over 4 days to a total of three courses, with a 2-week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer | ||
| 520 | |a RESULTS: Ninety-nine (85%) completed three courses. Overall subjective response rate was 77%. Median overall survival and progression-free survival were 12 months (95% confidence interval [CI]: 8-20) and 8 months (95% CI: 6-10), with numerically higher overall survival in oral cancer. The treatment was well tolerated, with no on-treatment hospitalization or grade 3-4 toxicities | ||
| 520 | |a CONCLUSION: The modified QUAD SHOT regimen is practical for palliation in head and neck cancers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a QUAD SHOT | |
| 650 | 4 | |a advanced oral cancer | |
| 650 | 4 | |a head and neck cancer | |
| 650 | 4 | |a hypofractionated radiotherapy | |
| 650 | 4 | |a oral cancer | |
| 650 | 4 | |a palliative radiotherapy | |
| 700 | 1 | |a Mallick, Indranil |e verfasserin |4 aut | |
| 700 | 1 | |a Mukherjee, Prattusha |e verfasserin |4 aut | |
| 700 | 1 | |a Chakraborty, Santam |e verfasserin |4 aut | |
| 700 | 1 | |a Bhattacharyya, Tapesh |e verfasserin |4 aut | |
| 700 | 1 | |a S, Moses Arunsingh |e verfasserin |4 aut | |
| 700 | 1 | |a Achari, Rimpa Basu |e verfasserin |4 aut | |
| 700 | 1 | |a Chatterjee, Sanjoy |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Head & neck |d 1996 |g (2024) vom: 25. März |w (DE-627)NLM012791806 |x 1097-0347 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:25 |g month:03 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/hed.27730 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 25 |c 03 | ||