Should I Take Aspirin? (SITA) : RCT of a decision aid for cancer chemoprevention
Copyright © 2024, The Authors..
Background Australian guidelines recommend that all people aged 50-70 years old consider taking low-dose aspirin to reduce the risk of colorectal cancer (CRC). Aim To determine the effect of a consultation with a researcher in general practice using a decision aid about taking low-dose aspirin to prevent CRC on informed decision-making and low-dose aspirin uptake compared to a general CRC prevention brochure. Design and Setting Individually randomised controlled trial in six general practices in Victoria, Australia, from October 2020 to March 2021. Method Patients aged 50-70 years attending a general practitioner (GP) were recruited consecutively. The intervention was a consultation using a decision aid to discuss taking aspirin to reduce CRC risk; control consultations discussed reducing CRC risk generally. The self-reported co-primary outcomes were informed choices about taking aspirin at one month and low-dose aspirin uptake at six months. Results 261 participants (86% of eligible patients) were randomised into trial arms (129 intervention, 132 control). 17.7% (20/113) of intervention and 7.6% (9/118) control participants reported making an informed choice at one month, an estimated 9.1% (95% CI 0.29% to 18.5) between-arm difference in proportions [odds ratio (OR) 2.47 (97.5% CI:0.94 to 6.52) p=0.074]. The proportions of individuals who reported using aspirin at six months were: 10.2% (12/118) intervention vs 13.8% (16/116) control (estimated between-arm difference: -4.0% (95% CI: -13.5 to 5.5); [OR= 0.68 (97.5% CI:0.27 to 1.70), p= 0.692]. Conclusion The decision aid improved informed decision-making; but has little effect on long-term regular use of aspirin to reduce CRC risk.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The British journal of general practice : the journal of the Royal College of General Practitioners - (2024) vom: 25. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Onwuka, Shakira R [VerfasserIn] |
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Date Revised 25.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.3399/BJGP.2023.0385 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370173465 |
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| 100 | 1 | |a Onwuka, Shakira R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Should I Take Aspirin? (SITA) |b RCT of a decision aid for cancer chemoprevention |
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| 520 | |a Copyright © 2024, The Authors. | ||
| 520 | |a Background Australian guidelines recommend that all people aged 50-70 years old consider taking low-dose aspirin to reduce the risk of colorectal cancer (CRC). Aim To determine the effect of a consultation with a researcher in general practice using a decision aid about taking low-dose aspirin to prevent CRC on informed decision-making and low-dose aspirin uptake compared to a general CRC prevention brochure. Design and Setting Individually randomised controlled trial in six general practices in Victoria, Australia, from October 2020 to March 2021. Method Patients aged 50-70 years attending a general practitioner (GP) were recruited consecutively. The intervention was a consultation using a decision aid to discuss taking aspirin to reduce CRC risk; control consultations discussed reducing CRC risk generally. The self-reported co-primary outcomes were informed choices about taking aspirin at one month and low-dose aspirin uptake at six months. Results 261 participants (86% of eligible patients) were randomised into trial arms (129 intervention, 132 control). 17.7% (20/113) of intervention and 7.6% (9/118) control participants reported making an informed choice at one month, an estimated 9.1% (95% CI 0.29% to 18.5) between-arm difference in proportions [odds ratio (OR) 2.47 (97.5% CI:0.94 to 6.52) p=0.074]. The proportions of individuals who reported using aspirin at six months were: 10.2% (12/118) intervention vs 13.8% (16/116) control (estimated between-arm difference: -4.0% (95% CI: -13.5 to 5.5); [OR= 0.68 (97.5% CI:0.27 to 1.70), p= 0.692]. Conclusion The decision aid improved informed decision-making; but has little effect on long-term regular use of aspirin to reduce CRC risk | ||
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| 700 | 1 | |a Boyd, Lucy |e verfasserin |4 aut | |
| 700 | 1 | |a Wijesuriya, Rushani |e verfasserin |4 aut | |
| 700 | 1 | |a Broun, Kate |e verfasserin |4 aut | |
| 700 | 1 | |a Marker, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Shub, Max |e verfasserin |4 aut | |
| 700 | 1 | |a McIntosh, Jennifer G |e verfasserin |4 aut | |
| 700 | 1 | |a Macrae, Finlay |e verfasserin |4 aut | |
| 700 | 1 | |a Chondros, Patty |e verfasserin |4 aut | |
| 700 | 1 | |a Saya, Sibel |e verfasserin |4 aut | |
| 700 | 1 | |a Novy, Kitty |e verfasserin |4 aut | |
| 700 | 1 | |a Jenkins, Mark A |e verfasserin |4 aut | |
| 700 | 1 | |a Walter, Fiona M |e verfasserin |4 aut | |
| 700 | 1 | |a Trevena, Lyndal |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez Gutierrez, Javiera |e verfasserin |4 aut | |
| 700 | 1 | |a Fishman, George |e verfasserin |4 aut | |
| 700 | 1 | |a Emery, Jon |e verfasserin |4 aut | |
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