Ethnic differences in depression and anxiety among adults with atopic eczema : Population-based matched cohort studies within UK primary care
© 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology..
BACKGROUND: Evidence demonstrates that individuals with atopic eczema (eczema) have increased depression and anxiety; however, the role of ethnicity in these associations is poorly understood. We aimed to investigate whether associations between eczema and depression or anxiety differed between adults from white and minority ethnic groups in the UK.
METHODS: We used UK Clinical Practice Research Datalink GOLD to conduct matched cohort studies of adults (≥18 years) with ethnicity recorded in primary care electronic health records (April 2006-January 2020). We matched (age, sex, practice) adults with eczema to up to five adults without. We used stratified Cox regression with an interaction between eczema and ethnicity, to estimate hazard ratios (HRs) for associations between eczema and incident depression and anxiety in individuals from white ethnic groups and a pooled minority ethnic group (adults from Black, South Asian, Mixed and Other groups).
RESULTS: We identified separate cohorts for depression (215,073 with eczema matched to 646,539 without) and anxiety (242,598 with eczema matched to 774,113 without). After adjusting for matching variables and potential confounders (age, sex, practice, deprivation, calendar period), we found strong evidence (p < 0.01) of ethnic differences in associations between eczema and depression (minority ethnic groups: HR = 1.33, 95% CI = 1.22,1.45; white ethnic groups: HR = 1.15, 95% CI = 1.12,1.17) and anxiety (minority ethnic groups: HR = 1.41, 95% CI = 1.28,1.55; white ethnic groups: HR = 1.17, 95% CI = 1.14,1.19).
CONCLUSIONS: Adults with eczema from minority ethnic groups appear to be at increased depression and anxiety risk compared with their white counterparts. Culturally adapted mental health promotion and prevention strategies should be considered in individuals with eczema from minority ethnic groups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Clinical and translational allergy - 14(2024), 3 vom: 25. März, Seite e12348 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Adesanya, Elizabeth I [VerfasserIn] |
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| Links: |
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| Themen: |
Anxiety |
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| Anmerkungen: |
Date Revised 27.03.2024 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/clt2.12348 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Adesanya, Elizabeth I |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ethnic differences in depression and anxiety among adults with atopic eczema |b Population-based matched cohort studies within UK primary care |
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| 520 | |a © 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. | ||
| 520 | |a BACKGROUND: Evidence demonstrates that individuals with atopic eczema (eczema) have increased depression and anxiety; however, the role of ethnicity in these associations is poorly understood. We aimed to investigate whether associations between eczema and depression or anxiety differed between adults from white and minority ethnic groups in the UK | ||
| 520 | |a METHODS: We used UK Clinical Practice Research Datalink GOLD to conduct matched cohort studies of adults (≥18 years) with ethnicity recorded in primary care electronic health records (April 2006-January 2020). We matched (age, sex, practice) adults with eczema to up to five adults without. We used stratified Cox regression with an interaction between eczema and ethnicity, to estimate hazard ratios (HRs) for associations between eczema and incident depression and anxiety in individuals from white ethnic groups and a pooled minority ethnic group (adults from Black, South Asian, Mixed and Other groups) | ||
| 520 | |a RESULTS: We identified separate cohorts for depression (215,073 with eczema matched to 646,539 without) and anxiety (242,598 with eczema matched to 774,113 without). After adjusting for matching variables and potential confounders (age, sex, practice, deprivation, calendar period), we found strong evidence (p < 0.01) of ethnic differences in associations between eczema and depression (minority ethnic groups: HR = 1.33, 95% CI = 1.22,1.45; white ethnic groups: HR = 1.15, 95% CI = 1.12,1.17) and anxiety (minority ethnic groups: HR = 1.41, 95% CI = 1.28,1.55; white ethnic groups: HR = 1.17, 95% CI = 1.14,1.19) | ||
| 520 | |a CONCLUSIONS: Adults with eczema from minority ethnic groups appear to be at increased depression and anxiety risk compared with their white counterparts. Culturally adapted mental health promotion and prevention strategies should be considered in individuals with eczema from minority ethnic groups | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a anxiety | |
| 650 | 4 | |a atopic eczema | |
| 650 | 4 | |a depression | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a ethnicity | |
| 700 | 1 | |a Henderson, Alasdair |e verfasserin |4 aut | |
| 700 | 1 | |a Hayes, Joseph F |e verfasserin |4 aut | |
| 700 | 1 | |a Lewin, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Mathur, Rohini |e verfasserin |4 aut | |
| 700 | 1 | |a Mulick, Amy |e verfasserin |4 aut | |
| 700 | 1 | |a Morton, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Langan, Sinéad M |e verfasserin |4 aut | |
| 700 | 1 | |a Mansfield, Kathryn E |e verfasserin |4 aut | |
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