Contemporary spectrum, characteristics, and outcomes of adult patients with rheumatic valvular disease in China : Insights from the China-VHD study
© 2024 The Authors..
Background: Rheumatic valvular disease (RVD) represents a significant health concern in developing countries, yet a scarcity of detailed data exists. This study conducts a comprehensive examination of RVD patients in China, exploring aspects of the disease's spectrum, characteristics, investigation, management, and outcomes.
Methods: The China Valvular Heart Disease (China-VHD) study, a nationwide, multicenter, prospective observational study, enrolled 13,917 adults with moderate-to-severe valvular heart disease from April to June 2018. Among these, 2402 patients with native RVD (19.7% of native VHD patients) were analyzed.
Results: Among the RVD patients, the median age was 57 years (interquartile range 50-65), with 82.5% falling within the 40-70 age range; females were notably predominant (63.9%). Rheumatic etiology prevailed, particularly in southern regions (48.8%). Multivalvular involvement was observed in 47.4% of RVD cases, and atrial fibrillation emerged as the most common comorbidity (43.2%). Severe RVD affected 64.2% of patients. Valvular interventions were undertaken by 66.9% of RVD patients, predominantly involving surgical valve replacement (90.8%). Adverse events, encompassing all-cause mortality and heart failure hospitalization, occurred in 7.3% of patients during the 2-year follow-up. Multivariable analysis identified factors such as age, geographical region, low body mass index, renal insufficiency, left atrial diameter, and left ventricular ejection fraction <50% (all P < 0.05) associated with adverse events, with valvular intervention emerging as a protective factor (HR: 0.201; 95%CI: 0.139 to 0.291; p < 0.001).
Conclusions: This study delivers a comprehensive evaluation of RVD patients in China, shedding light on the spectrum, characteristics, investigation, management, and outcomes of this prevalent condition.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
International journal of cardiology. Cardiovascular risk and prevention - 21(2024) vom: 20. März, Seite 200259 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Duan, Zhenya [VerfasserIn] |
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| Links: |
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| Themen: |
Characteristics |
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| Anmerkungen: |
Date Revised 26.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.ijcrp.2024.200259 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370146727 |
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| 100 | 1 | |a Duan, Zhenya |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Contemporary spectrum, characteristics, and outcomes of adult patients with rheumatic valvular disease in China |b Insights from the China-VHD study |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 26.03.2024 | ||
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| 520 | |a © 2024 The Authors. | ||
| 520 | |a Background: Rheumatic valvular disease (RVD) represents a significant health concern in developing countries, yet a scarcity of detailed data exists. This study conducts a comprehensive examination of RVD patients in China, exploring aspects of the disease's spectrum, characteristics, investigation, management, and outcomes | ||
| 520 | |a Methods: The China Valvular Heart Disease (China-VHD) study, a nationwide, multicenter, prospective observational study, enrolled 13,917 adults with moderate-to-severe valvular heart disease from April to June 2018. Among these, 2402 patients with native RVD (19.7% of native VHD patients) were analyzed | ||
| 520 | |a Results: Among the RVD patients, the median age was 57 years (interquartile range 50-65), with 82.5% falling within the 40-70 age range; females were notably predominant (63.9%). Rheumatic etiology prevailed, particularly in southern regions (48.8%). Multivalvular involvement was observed in 47.4% of RVD cases, and atrial fibrillation emerged as the most common comorbidity (43.2%). Severe RVD affected 64.2% of patients. Valvular interventions were undertaken by 66.9% of RVD patients, predominantly involving surgical valve replacement (90.8%). Adverse events, encompassing all-cause mortality and heart failure hospitalization, occurred in 7.3% of patients during the 2-year follow-up. Multivariable analysis identified factors such as age, geographical region, low body mass index, renal insufficiency, left atrial diameter, and left ventricular ejection fraction <50% (all P < 0.05) associated with adverse events, with valvular intervention emerging as a protective factor (HR: 0.201; 95%CI: 0.139 to 0.291; p < 0.001) | ||
| 520 | |a Conclusions: This study delivers a comprehensive evaluation of RVD patients in China, shedding light on the spectrum, characteristics, investigation, management, and outcomes of this prevalent condition | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Characteristics | |
| 650 | 4 | |a Management | |
| 650 | 4 | |a Outcomes | |
| 650 | 4 | |a Rheumatic valvular disease | |
| 700 | 1 | |a Ye, Yunqing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhe |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qingrong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Zhenyan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Weiwei |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Zikai |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Haitong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Qinghao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Bincheng |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Junxing |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Haocheng |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Runlin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Haiyan |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yongjian |e verfasserin |4 aut | |
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