Associations of ALT/AST, a marker of hepatosteatosis, with pulse rate in young women and with blood pressure in middle-aged women independently of abdominal fat accumulation and insulin resistance
© The Japan Diabetes Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law..
We examined whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatosteatosis, may be associated with a wider constellation of variables related to metabolic syndrome in Japanese women. Body fat and distribution, and metabolic syndrome-related variables were measured in 311 young and 148 middle-aged women. We had Pearson's correlation analysis and then stepwise multivariate linear regression analyses. In both middle-aged and young women, ALT/AST was associated with homeostasis model assessment insulin resistance (HOMA-IR), trunk/leg fat ratio and pulse rate. In middle-aged women but not in young women, ALT/AST was associated with waist circumference, fasting glucose, triglyceride, HDL cholesterol (inversely), systolic, diastolic and mean blood pressure (BP). Further, in middle-aged women only, the ratio was associated with BMI, percentage body fat, apolipoprotein B and plasminogen activator inhibitor-1. Among these variables, pulse rate in young women and systolic BP in middle-aged women were associated with ALT/AST independently of trunk/leg fat ratio, a sophisticated measures of abdominal fat accumulation, HOMA-IR, fasting glucose, triglyceride and HDL cholesterol. In conclusion, ALT/AST was associated with pulse rate in young women and with systolic BP in middle-aged women independently of abdominal fat accumulation and insulin resistance. It is noted that their waist circumference averaged < 80 cm and ALT < 30 U/L, suggesting minimum accumulation of abdominal and hepatic fat, respectively, key drivers of insulin resistance and metabolic syndrome.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-023-00689-z.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Diabetology international - 15(2024), 2 vom: 30. März, Seite 270-277 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Minato-Inokawa, Satomi [VerfasserIn] |
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| Links: |
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| Themen: |
ALT/AST |
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| Anmerkungen: |
Date Revised 26.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s13340-023-00689-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a We examined whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatosteatosis, may be associated with a wider constellation of variables related to metabolic syndrome in Japanese women. Body fat and distribution, and metabolic syndrome-related variables were measured in 311 young and 148 middle-aged women. We had Pearson's correlation analysis and then stepwise multivariate linear regression analyses. In both middle-aged and young women, ALT/AST was associated with homeostasis model assessment insulin resistance (HOMA-IR), trunk/leg fat ratio and pulse rate. In middle-aged women but not in young women, ALT/AST was associated with waist circumference, fasting glucose, triglyceride, HDL cholesterol (inversely), systolic, diastolic and mean blood pressure (BP). Further, in middle-aged women only, the ratio was associated with BMI, percentage body fat, apolipoprotein B and plasminogen activator inhibitor-1. Among these variables, pulse rate in young women and systolic BP in middle-aged women were associated with ALT/AST independently of trunk/leg fat ratio, a sophisticated measures of abdominal fat accumulation, HOMA-IR, fasting glucose, triglyceride and HDL cholesterol. In conclusion, ALT/AST was associated with pulse rate in young women and with systolic BP in middle-aged women independently of abdominal fat accumulation and insulin resistance. It is noted that their waist circumference averaged < 80 cm and ALT < 30 U/L, suggesting minimum accumulation of abdominal and hepatic fat, respectively, key drivers of insulin resistance and metabolic syndrome | ||
| 520 | |a Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-023-00689-z | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ALT/AST | |
| 650 | 4 | |a Blood pressure | |
| 650 | 4 | |a Hepatosteatosis | |
| 650 | 4 | |a Metabolic syndrome | |
| 650 | 4 | |a Pulse rate | |
| 650 | 4 | |a Triglyceride | |
| 700 | 1 | |a Tsuboi-Kaji, Ayaka |e verfasserin |4 aut | |
| 700 | 1 | |a Honda, Mari |e verfasserin |4 aut | |
| 700 | 1 | |a Takeuchi, Mika |e verfasserin |4 aut | |
| 700 | 1 | |a Kitaoka, Kaori |e verfasserin |4 aut | |
| 700 | 1 | |a Kurata, Miki |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Kazumi, Tsutomu |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuo, Keisuke |e verfasserin |4 aut | |
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