The effect of vitamin D deficiency on platelet parameters in patients with COVID-19
Copyright © 2024 Talebzadeh, Ghaffari, Ghaffari, Yazdanpanah, Yousefi Goltappeh, Eslami and Ghasemi..
Introduction: Since there is very little information about the relationship between platelet parameters and vitamin D concentration in patients with COVID-19, the aim of this study is to investigate the relationship between serum vitamin D level and platelet parameters in patients with COVID-19 and to compare these parameters in patients with COVID-19 without vitamin D deficiency and, subsequently, the prognostic value of these parameters in cases of vitamin D deficiency.
Methods: Seven hundred and forty-three patients diagnosed with COVID-19 were enrolled in this study. Patients were divided into two groups: those with and without vitamin D deficiency. The associations between platelet indices and vitamin D levels were analyzed by Pearson's correlation analysis and a one-way ANOVA test.
Results: Platelet count and mean platelet volume (MPV) were significantly higher in the patients with vitamin D deficiency than in the patients without vitamin D deficiency. There was a significant negative correlation between platelet count and MPV with vitamin D levels in patients with vitamin D deficiency (r = -0.835, P = 0.001 & r = -0.324, P = 0.042, respectively). Vitamin D levels in COVID-19 patients can determine the platelet count and MPV of the patients.
Discussion: The aforementioned results imply that maintaining an elevated concentration of vitamin D in COVID-19 patients is important because it is associated with a decrease in MPV, which in turn reduces susceptibility to diseases such as coronary artery disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in cellular and infection microbiology - 14(2024) vom: 08., Seite 1360075 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Talebzadeh, Amirhossein [VerfasserIn] |
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| Links: |
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| Themen: |
1406-16-2 |
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| Anmerkungen: |
Date Completed 26.03.2024 Date Revised 26.03.2024 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fcimb.2024.1360075 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370137485 |
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| 100 | 1 | |a Talebzadeh, Amirhossein |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effect of vitamin D deficiency on platelet parameters in patients with COVID-19 |
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| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Talebzadeh, Ghaffari, Ghaffari, Yazdanpanah, Yousefi Goltappeh, Eslami and Ghasemi. | ||
| 520 | |a Introduction: Since there is very little information about the relationship between platelet parameters and vitamin D concentration in patients with COVID-19, the aim of this study is to investigate the relationship between serum vitamin D level and platelet parameters in patients with COVID-19 and to compare these parameters in patients with COVID-19 without vitamin D deficiency and, subsequently, the prognostic value of these parameters in cases of vitamin D deficiency | ||
| 520 | |a Methods: Seven hundred and forty-three patients diagnosed with COVID-19 were enrolled in this study. Patients were divided into two groups: those with and without vitamin D deficiency. The associations between platelet indices and vitamin D levels were analyzed by Pearson's correlation analysis and a one-way ANOVA test | ||
| 520 | |a Results: Platelet count and mean platelet volume (MPV) were significantly higher in the patients with vitamin D deficiency than in the patients without vitamin D deficiency. There was a significant negative correlation between platelet count and MPV with vitamin D levels in patients with vitamin D deficiency (r = -0.835, P = 0.001 & r = -0.324, P = 0.042, respectively). Vitamin D levels in COVID-19 patients can determine the platelet count and MPV of the patients | ||
| 520 | |a Discussion: The aforementioned results imply that maintaining an elevated concentration of vitamin D in COVID-19 patients is important because it is associated with a decrease in MPV, which in turn reduces susceptibility to diseases such as coronary artery disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a mean platelet volume | |
| 650 | 4 | |a platelets | |
| 650 | 4 | |a thrombocytosis | |
| 650 | 4 | |a vitamin D | |
| 650 | 7 | |a Vitamin D |2 NLM | |
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| 700 | 1 | |a Ghaffari, Hadi |e verfasserin |4 aut | |
| 700 | 1 | |a Ghaffari, Kazem |e verfasserin |4 aut | |
| 700 | 1 | |a Yazdanpanah, Sorur |e verfasserin |4 aut | |
| 700 | 1 | |a Yousefi Goltappeh, Bahman |e verfasserin |4 aut | |
| 700 | 1 | |a Eslami, Majid |e verfasserin |4 aut | |
| 700 | 1 | |a Ghasemi, Ali |e verfasserin |4 aut | |
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