Phosphine-Catalyzed [4 + 3] Annulation of β'-Acetoxy Allenoates with 1C,3N-Dinucleophiles : Access to Functionalized Azepine Derivatives
A novel method for the synthesis of functionalized azepine derivatives has been developed through a phosphine-catalyzed [4 + 3] annulation of β'-acetoxy allenoates with benzimidazole-derived 1C,3N-dinucleophiles. This approach demonstrates high efficiency and yields ranging from moderate to excellent. The reaction exhibits a wide substrate scope under the optimized conditions. Furthermore, an initial exploration of the asymmetric variant of this reaction has been conducted, utilizing phosphine (R)-SITCP as the catalyst.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
The Journal of organic chemistry - 89(2024), 7 vom: 05. Apr., Seite 4784-4791 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ni, Chunjie [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 05.04.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.joc.4c00011 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370129210 |
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| 245 | 1 | 0 | |a Phosphine-Catalyzed [4 + 3] Annulation of β'-Acetoxy Allenoates with 1C,3N-Dinucleophiles |b Access to Functionalized Azepine Derivatives |
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| 500 | |a Date Revised 05.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A novel method for the synthesis of functionalized azepine derivatives has been developed through a phosphine-catalyzed [4 + 3] annulation of β'-acetoxy allenoates with benzimidazole-derived 1C,3N-dinucleophiles. This approach demonstrates high efficiency and yields ranging from moderate to excellent. The reaction exhibits a wide substrate scope under the optimized conditions. Furthermore, an initial exploration of the asymmetric variant of this reaction has been conducted, utilizing phosphine (R)-SITCP as the catalyst | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Liang, Zhanhang |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Xiaojuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chen |e verfasserin |4 aut | |
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