Clinical perspective on topical vaccination strategies
Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved..
Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined herein as the introduction of a vaccine to any of the three layers of the human skin, has attracted interest in recent years as an alternative vaccination approach to the conventional intramuscular administration because of its potential to be needle-free and induce a superior immune response against pathogens. In this review, we describe recent progress in developing topical vaccines, highlight progress in the development of delivery technologies for topical vaccines, discuss potential factors that might impact the topical vaccine efficacy, and provide an overview of the current clinical landscape of topical vaccines.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:208 |
---|---|
Enthalten in: |
Advanced drug delivery reviews - 208(2024) vom: 23. Apr., Seite 115292 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
G Popova, Petya [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 22.04.2024 Date Revised 22.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.addr.2024.115292 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM370122976 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM370122976 | ||
003 | DE-627 | ||
005 | 20240422232306.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240325s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.addr.2024.115292 |2 doi | |
028 | 5 | 2 | |a pubmed24n1383.xml |
035 | |a (DE-627)NLM370122976 | ||
035 | |a (NLM)38522725 | ||
035 | |a (PII)S0169-409X(24)00114-5 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a G Popova, Petya |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical perspective on topical vaccination strategies |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 22.04.2024 | ||
500 | |a Date Revised 22.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved. | ||
520 | |a Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined herein as the introduction of a vaccine to any of the three layers of the human skin, has attracted interest in recent years as an alternative vaccination approach to the conventional intramuscular administration because of its potential to be needle-free and induce a superior immune response against pathogens. In this review, we describe recent progress in developing topical vaccines, highlight progress in the development of delivery technologies for topical vaccines, discuss potential factors that might impact the topical vaccine efficacy, and provide an overview of the current clinical landscape of topical vaccines | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Clinical studies | |
650 | 4 | |a Drug delivery | |
650 | 4 | |a Intradermal | |
650 | 4 | |a Nanoparticle | |
650 | 4 | |a Permeation enhancer | |
650 | 4 | |a Skin microbiota | |
650 | 4 | |a Subcutaneous | |
650 | 4 | |a Topical delivery | |
650 | 4 | |a Topical vaccination | |
650 | 4 | |a Vaccine adjuvants | |
650 | 7 | |a Vaccines |2 NLM | |
650 | 7 | |a Adjuvants, Immunologic |2 NLM | |
650 | 7 | |a Antigens |2 NLM | |
700 | 1 | |a Chen, Sunny P |e verfasserin |4 aut | |
700 | 1 | |a Liao, Suiyang |e verfasserin |4 aut | |
700 | 1 | |a Sadarangani, Manish |e verfasserin |4 aut | |
700 | 1 | |a Blakney, Anna K |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Advanced drug delivery reviews |d 1995 |g 208(2024) vom: 23. Apr., Seite 115292 |w (DE-627)NLM086826522 |x 1872-8294 |7 nnns |
773 | 1 | 8 | |g volume:208 |g year:2024 |g day:23 |g month:04 |g pages:115292 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.addr.2024.115292 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 208 |j 2024 |b 23 |c 04 |h 115292 |