Emerge of colorectal cancer in Lynch syndrome despite colonoscopy surveillance : A challenge of hide and seek
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
Even with colonoscopy surveillance, Lynch syndromes (LS) carriers still develop colorectal cancer (CRC). The cumulative incidence of CRCs under colonoscopy surveillance varies depending on the affected mismatch repair (MMR) gene. However, the precise mechanisms driving these epidemiological patterns remain incompletely understood. In recent years, several potential mechanisms explaining the occurrence of CRCs during colonoscopy surveillance have been proposed in individuals with and without LS. These encompass biological factors like concealed/accelerated carcinogenesis through a bypassed adenoma stage and accelerated progression from adenomas. Alongside these, various colonoscopy-related factors may contribute to formation of CRCs under colonoscopy surveillance, like missed yet detectable (pre)cancerous lesions, detected yet incompletely removed (pre)cancerous lesions, and colonoscopy-induced carcinogenesis due to tumor cell reimplantation. In this comprehensive literature update, we reviewed these potential factors and evaluated their relevance to each MMR group in an attempt to raise further awareness and stimulate research regarding this conflicting phenomenon.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:197 |
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| Enthalten in: |
Critical reviews in oncology/hematology - 197(2024) vom: 21. März, Seite 104331 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Helderman, Noah C [VerfasserIn] |
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| Links: |
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| Themen: |
Colonoscopy surveillance |
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| Anmerkungen: |
Date Revised 24.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.critrevonc.2024.104331 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370108582 |
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| 245 | 1 | 0 | |a Emerge of colorectal cancer in Lynch syndrome despite colonoscopy surveillance |b A challenge of hide and seek |
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| 500 | |a Date Revised 24.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Even with colonoscopy surveillance, Lynch syndromes (LS) carriers still develop colorectal cancer (CRC). The cumulative incidence of CRCs under colonoscopy surveillance varies depending on the affected mismatch repair (MMR) gene. However, the precise mechanisms driving these epidemiological patterns remain incompletely understood. In recent years, several potential mechanisms explaining the occurrence of CRCs during colonoscopy surveillance have been proposed in individuals with and without LS. These encompass biological factors like concealed/accelerated carcinogenesis through a bypassed adenoma stage and accelerated progression from adenomas. Alongside these, various colonoscopy-related factors may contribute to formation of CRCs under colonoscopy surveillance, like missed yet detectable (pre)cancerous lesions, detected yet incompletely removed (pre)cancerous lesions, and colonoscopy-induced carcinogenesis due to tumor cell reimplantation. In this comprehensive literature update, we reviewed these potential factors and evaluated their relevance to each MMR group in an attempt to raise further awareness and stimulate research regarding this conflicting phenomenon | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Colonoscopy surveillance | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Incident colorectal cancer | |
| 650 | 4 | |a Lynch syndrome | |
| 650 | 4 | |a Mismatch repair | |
| 650 | 4 | |a Post-colonoscopy colorectal cancer | |
| 700 | 1 | |a van Leerdam, Monique E |e verfasserin |4 aut | |
| 700 | 1 | |a Kloor, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Ahadova, Aysel |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen, Maartje |e verfasserin |4 aut | |
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