Distribution of human papillomavirus among Vietnamese women with cervical cancer and unusual genetic variability of HPV16
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved..
HPV16, with typical mutations that differ in geographical distribution and carcinogenic potency, has implications for cervical cancer screening, clinical diagnosis, and treatment. DNASTAR and MEGA were used to identify HPV16 variants and construct a phylogenetic tree. The most prevalent HPV genotypes were HPV16 (63.9%), HPV18 (26.7%), and other HPV (6.9%). HPV16 alterations were found in all E6, E7, and L1 genes, including 15 missense and 18 synonymous mutations. Missense mutations include R10G, Q14H, D25E, H78Y, L83V (E6); M29V, R35K, L78R, L95P (E7); H73Y, T176 N, N178T, T317P, T386S, L472F/I (L1). HPV16 sublineages include A1 (17.2%), A2 (0.9%), A3 (56.0%), A4 (19.0%), D1 (4.3%), and D3 (2.6%). Although several mutations in the oncoproteins E6, E7, and L1 have been detected, mutations known to be associated with cervical cancer risk, such as D25E and L83V, occur at a relatively low frequency. This suggests that HPV16 mutations are associated with cervical cancer through a complicated mechanism.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:594 |
---|---|
Enthalten in: |
Virology - 594(2024) vom: 30. Apr., Seite 110058 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Le, Van Nam [VerfasserIn] |
---|
Links: |
---|
Themen: |
Cervical cancer |
---|
Anmerkungen: |
Date Completed 09.04.2024 Date Revised 09.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.virol.2024.110058 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM370103580 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM370103580 | ||
003 | DE-627 | ||
005 | 20240409232716.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240324s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.virol.2024.110058 |2 doi | |
028 | 5 | 2 | |a pubmed24n1370.xml |
035 | |a (DE-627)NLM370103580 | ||
035 | |a (NLM)38520797 | ||
035 | |a (PII)S0042-6822(24)00079-5 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Le, Van Nam |e verfasserin |4 aut | |
245 | 1 | 0 | |a Distribution of human papillomavirus among Vietnamese women with cervical cancer and unusual genetic variability of HPV16 |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 09.04.2024 | ||
500 | |a Date Revised 09.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. | ||
520 | |a HPV16, with typical mutations that differ in geographical distribution and carcinogenic potency, has implications for cervical cancer screening, clinical diagnosis, and treatment. DNASTAR and MEGA were used to identify HPV16 variants and construct a phylogenetic tree. The most prevalent HPV genotypes were HPV16 (63.9%), HPV18 (26.7%), and other HPV (6.9%). HPV16 alterations were found in all E6, E7, and L1 genes, including 15 missense and 18 synonymous mutations. Missense mutations include R10G, Q14H, D25E, H78Y, L83V (E6); M29V, R35K, L78R, L95P (E7); H73Y, T176 N, N178T, T317P, T386S, L472F/I (L1). HPV16 sublineages include A1 (17.2%), A2 (0.9%), A3 (56.0%), A4 (19.0%), D1 (4.3%), and D3 (2.6%). Although several mutations in the oncoproteins E6, E7, and L1 have been detected, mutations known to be associated with cervical cancer risk, such as D25E and L83V, occur at a relatively low frequency. This suggests that HPV16 mutations are associated with cervical cancer through a complicated mechanism | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Cervical cancer | |
650 | 4 | |a Genotype | |
650 | 4 | |a HPV | |
650 | 4 | |a Lineage | |
650 | 4 | |a Sublineage | |
650 | 7 | |a Oncogene Proteins, Viral |2 NLM | |
650 | 7 | |a Papillomavirus E7 Proteins |2 NLM | |
700 | 1 | |a Le, Van Nguyen Bang |e verfasserin |4 aut | |
700 | 1 | |a Hoang, Xuan Son |e verfasserin |4 aut | |
700 | 1 | |a Le, Van Duyet |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Virology |d 1955 |g 594(2024) vom: 30. Apr., Seite 110058 |w (DE-627)NLM000011347 |x 1096-0341 |7 nnns |
773 | 1 | 8 | |g volume:594 |g year:2024 |g day:30 |g month:04 |g pages:110058 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.virol.2024.110058 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 594 |j 2024 |b 30 |c 04 |h 110058 |