Molecular docking of quercetin : a promising approach for the development of new anti-inflammatory and analgesic drugs
The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde test. Additionally, evaluation of its anti-inflammatory activity showed a reduction in ear oedema. However, it is important to note that quercetin administration has not been shown to significantly reduce yeast-induced hyperthermia. The docking study revealed the high inhibitory potential of quercetin against the COX-2 receptor.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Natural product research - (2024) vom: 23. März, Seite 1-10 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ettitaou, Amina [VerfasserIn] |
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| Links: |
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| Themen: |
Analgesic activity |
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| Anmerkungen: |
Date Revised 23.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1080/14786419.2024.2333053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370098188 |
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| 520 | |a The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde test. Additionally, evaluation of its anti-inflammatory activity showed a reduction in ear oedema. However, it is important to note that quercetin administration has not been shown to significantly reduce yeast-induced hyperthermia. The docking study revealed the high inhibitory potential of quercetin against the COX-2 receptor | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Quercetin | |
| 650 | 4 | |a analgesic activity | |
| 650 | 4 | |a anti-inflammatory activity | |
| 650 | 4 | |a antipyretic activity | |
| 650 | 4 | |a molecular docking | |
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| 700 | 1 | |a Oubahmane, Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Aboufatima, Rachida |e verfasserin |4 aut | |
| 700 | 1 | |a Elyazouli, Loubna |e verfasserin |4 aut | |
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