Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage
© 2024. The Author(s)..
After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ginsenoside Rb1 and ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities in scavenging ABTS + free radicals and iron ions in solution. After intrathecal injection, the distribution of RBCQDs is predominantly localized in the subarachnoid space. RBCQDs can eliminate ROS and chelate iron ions within the meningeal system. Treatment with RBCQDs significantly improves blood flow in the meningeal system, effectively protecting dying neurons, improving neurological function, and providing a new therapeutic approach for the clinical treatment of ICH.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Journal of nanobiotechnology - 22(2024), 1 vom: 22. März, Seite 125 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tang, Xiaolong [VerfasserIn] |
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| Links: |
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| Themen: |
7413S0WMH6 |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 26.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12951-024-02368-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370095944 |
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| 520 | |a © 2024. The Author(s). | ||
| 520 | |a After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ginsenoside Rb1 and ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities in scavenging ABTS + free radicals and iron ions in solution. After intrathecal injection, the distribution of RBCQDs is predominantly localized in the subarachnoid space. RBCQDs can eliminate ROS and chelate iron ions within the meningeal system. Treatment with RBCQDs significantly improves blood flow in the meningeal system, effectively protecting dying neurons, improving neurological function, and providing a new therapeutic approach for the clinical treatment of ICH | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Yang, Xinyu |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Yamei |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Miaojing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yuanyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhe |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Guangyu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Tu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Xingen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shiyong |e verfasserin |4 aut | |
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