Genetic and biologic risk factors associated with hernia formation : A review
Published by Elsevier Inc..
BACKGROUND: This systematic review aims to identify genetic and biologic markers associated with abdominal hernia formation.
METHODS: Following PRIMSA-guidelines, we searched PubMed, MEDLINE, Embase, Scopus, and COCHRANE databases.
RESULTS: Of 5946 studies, 65 were selected, excluding parastomal hernias due to insufficient data. For inguinal hernias, five studies unveiled 92 susceptible loci across 66 genes, predominantly linked to immune responses. Eleven studies observed elevated MMP-2 levels, with seven highlighting greater MMP-2 in direct compared to indirect inguinal hernias. One incisional hernia study identified unique gene-expression profiles in 174 genes associated with inflammation and cell-adhesion. In hiatal hernias, several genetic risk loci were identified. For all hernia categories, type I/III collagen ratios diminished.
CONCLUSIONS: Biological markers in inguinal hernias appears consistent. Yet, the genetic predisposition in incisional hernias remains elusive. Further research to elucidate these genetic and biological intricacies can pave the way for more individualized patient care.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of surgery - (2024) vom: 27. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Amro, Chris [VerfasserIn] |
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| Links: |
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| Themen: |
Abdominal hernia |
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| Anmerkungen: |
Date Revised 22.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.amjsurg.2024.02.029 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370089731 |
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| 245 | 1 | 0 | |a Genetic and biologic risk factors associated with hernia formation |b A review |
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| 500 | |a Date Revised 22.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Published by Elsevier Inc. | ||
| 520 | |a BACKGROUND: This systematic review aims to identify genetic and biologic markers associated with abdominal hernia formation | ||
| 520 | |a METHODS: Following PRIMSA-guidelines, we searched PubMed, MEDLINE, Embase, Scopus, and COCHRANE databases | ||
| 520 | |a RESULTS: Of 5946 studies, 65 were selected, excluding parastomal hernias due to insufficient data. For inguinal hernias, five studies unveiled 92 susceptible loci across 66 genes, predominantly linked to immune responses. Eleven studies observed elevated MMP-2 levels, with seven highlighting greater MMP-2 in direct compared to indirect inguinal hernias. One incisional hernia study identified unique gene-expression profiles in 174 genes associated with inflammation and cell-adhesion. In hiatal hernias, several genetic risk loci were identified. For all hernia categories, type I/III collagen ratios diminished | ||
| 520 | |a CONCLUSIONS: Biological markers in inguinal hernias appears consistent. Yet, the genetic predisposition in incisional hernias remains elusive. Further research to elucidate these genetic and biological intricacies can pave the way for more individualized patient care | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Abdominal hernia | |
| 650 | 4 | |a Biological factor | |
| 650 | 4 | |a Genetic marker | |
| 650 | 4 | |a Patient care | |
| 650 | 4 | |a Systematic review | |
| 650 | 4 | |a Therapeutic interventions | |
| 700 | 1 | |a Niu, Ellen F |e verfasserin |4 aut | |
| 700 | 1 | |a Deianni, Ellie |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Laurie |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Maylene |e verfasserin |4 aut | |
| 700 | 1 | |a Torkington, Jared |e verfasserin |4 aut | |
| 700 | 1 | |a Broach, Robyn B |e verfasserin |4 aut | |
| 700 | 1 | |a Maguire, Lillias H |e verfasserin |4 aut | |
| 700 | 1 | |a Damrauer, Scott M |e verfasserin |4 aut | |
| 700 | 1 | |a Itani, Kamal |e verfasserin |4 aut | |
| 700 | 1 | |a Fischer, John P |e verfasserin |4 aut | |
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