Minor ergosteroids and a 19-nor labdane-type diterpenoid with anti-inflammatory effects from Ganoderma lucidum
Copyright © 2024 Elsevier Ltd. All rights reserved..
A chemical investigation on the fruiting bodies of Ganoderma lucidum led to the isolation and identification of five undescribed ergosteroids including two des-D-steroids (3 and 4) and one rare 6/6/7/5-fused carbon skeletal ergosterol (5) along with one 19-nor labdane-type diterpenoid (6). Their structures including their absolute configurations, were assigned by spectroscopic methods, ECD calculations, and X-ray diffraction analysis. In addition, the anti-inflammatory activities of all the isolates were evaluated. The results indicated that compound 1 can significantly down-regulate the protein expression of iNOS and COX-2 at 20 μM in LPS- stimulated RAW264.7 cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:222 |
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| Enthalten in: |
Phytochemistry - 222(2024) vom: 20. März, Seite 114052 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cai, Dan [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-inflammatory |
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| Anmerkungen: |
Date Revised 30.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.phytochem.2024.114052 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 Elsevier Ltd. All rights reserved. | ||
| 520 | |a A chemical investigation on the fruiting bodies of Ganoderma lucidum led to the isolation and identification of five undescribed ergosteroids including two des-D-steroids (3 and 4) and one rare 6/6/7/5-fused carbon skeletal ergosterol (5) along with one 19-nor labdane-type diterpenoid (6). Their structures including their absolute configurations, were assigned by spectroscopic methods, ECD calculations, and X-ray diffraction analysis. In addition, the anti-inflammatory activities of all the isolates were evaluated. The results indicated that compound 1 can significantly down-regulate the protein expression of iNOS and COX-2 at 20 μM in LPS- stimulated RAW264.7 cells | ||
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| 700 | 1 | |a Tang, Xin-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Yong-Xian |e verfasserin |4 aut | |
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