Plant mucus-derived microgels : Blood-triggered gelation and strong hemostatic adhesion
Copyright © 2024. Published by Elsevier Ltd..
Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the microgels' gelation with the outcome of super extensibility, which leads to the microgels a strong hemostatic agent. We also found a tight gel adhesive layer formed upon microgels' contacting the blood on the tissue, where there is the coagulation factor XIII triggered to form a dense three-dimensional fibrin meshwork. The generated structures show that the microgels look like hard balls in the dispersed phase into the blood-produced fibrin mesh of a soft net phase. Both phases work together for a super-extension gel. We demonstrated the microgels' fast adhesion and hemostasis in the livers and hearts of rabbits and mini pigs. The microgels also promoted wound healing with good biocompatibility and biodegradability.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:307 |
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| Enthalten in: |
Biomaterials - 307(2024) vom: 15. Apr., Seite 122535 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Huang, Yu [VerfasserIn] |
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| Links: |
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| Themen: |
9001-31-4 |
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| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 01.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.biomaterials.2024.122535 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024. Published by Elsevier Ltd. | ||
| 520 | |a Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the microgels' gelation with the outcome of super extensibility, which leads to the microgels a strong hemostatic agent. We also found a tight gel adhesive layer formed upon microgels' contacting the blood on the tissue, where there is the coagulation factor XIII triggered to form a dense three-dimensional fibrin meshwork. The generated structures show that the microgels look like hard balls in the dispersed phase into the blood-produced fibrin mesh of a soft net phase. Both phases work together for a super-extension gel. We demonstrated the microgels' fast adhesion and hemostasis in the livers and hearts of rabbits and mini pigs. The microgels also promoted wound healing with good biocompatibility and biodegradability | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Blood-induced adhesion | |
| 650 | 4 | |a Blood-triggered gelation | |
| 650 | 4 | |a Hemostasis and adhesion | |
| 650 | 4 | |a Plant mucus microgels | |
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| 700 | 1 | |a Xu, Kaige |e verfasserin |4 aut | |
| 700 | 1 | |a Dan, Ruijue |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Shali |e verfasserin |4 aut | |
| 700 | 1 | |a Shu, Zhenzhen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Hangzong |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Chaoqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, Malcolm |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Shiming |e verfasserin |4 aut | |
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