Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy
© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH..
Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecond-laser ablation in liquids rapidly dissolve in physiological-like environment through the oxidation mechanism. The biodegradation of Ge nanoparticles is preserved in tumor cells in vitro and in normal tissues in mice with a half-life as short as 3.5 days. Biocompatibility of Ge NPs is confirmed in vivo by hematological, biochemical, and histological analyses. Strong optical absorption of Ge in the near-infrared spectral range enables photothermal treatment of engrafted tumors in vivo, following intravenous injection of Ge NPs. The photothermal therapy results in a 3.9-fold reduction of the EMT6/P adenocarcinoma tumor growth with significant prolongation of the mice survival. Excellent mass-extinction of Ge NPs (7.9 L g-1 cm-1 at 808 nm) enables photoacoustic imaging of bones and tumors, following intravenous and intratumoral administrations of the nanomaterial. As such, strongly absorbing near-infrared-light biodegradable Ge nanomaterial holds promise for advanced theranostics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - (2024) vom: 22. März, Seite e2307060 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Belyaev, Iaroslav B [VerfasserIn] |
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| Links: |
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| Themen: |
Biodegradable materials |
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| Anmerkungen: |
Date Revised 22.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/advs.202307060 |
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| funding: |
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NLM370063236 |
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| 520 | |a Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecond-laser ablation in liquids rapidly dissolve in physiological-like environment through the oxidation mechanism. The biodegradation of Ge nanoparticles is preserved in tumor cells in vitro and in normal tissues in mice with a half-life as short as 3.5 days. Biocompatibility of Ge NPs is confirmed in vivo by hematological, biochemical, and histological analyses. Strong optical absorption of Ge in the near-infrared spectral range enables photothermal treatment of engrafted tumors in vivo, following intravenous injection of Ge NPs. The photothermal therapy results in a 3.9-fold reduction of the EMT6/P adenocarcinoma tumor growth with significant prolongation of the mice survival. Excellent mass-extinction of Ge NPs (7.9 L g-1 cm-1 at 808 nm) enables photoacoustic imaging of bones and tumors, following intravenous and intratumoral administrations of the nanomaterial. As such, strongly absorbing near-infrared-light biodegradable Ge nanomaterial holds promise for advanced theranostics | ||
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| 650 | 4 | |a photoacoustic imaging | |
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| 700 | 1 | |a Zelepukin, Ivan V |e verfasserin |4 aut | |
| 700 | 1 | |a Kotelnikova, Polina A |e verfasserin |4 aut | |
| 700 | 1 | |a Tikhonowski, Gleb V |e verfasserin |4 aut | |
| 700 | 1 | |a Popov, Anton A |e verfasserin |4 aut | |
| 700 | 1 | |a Kapitannikova, Alina Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Barman, Jugal |e verfasserin |4 aut | |
| 700 | 1 | |a Kopylov, Alexey N |e verfasserin |4 aut | |
| 700 | 1 | |a Bratashov, Daniil N |e verfasserin |4 aut | |
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| 700 | 1 | |a Kabashin, Andrei V |e verfasserin |4 aut | |
| 700 | 1 | |a Deyev, Sergey M |e verfasserin |4 aut | |
| 700 | 1 | |a Zvyagin, Andrei V |e verfasserin |4 aut | |
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