A case report of treatment of a streptococcal brain abscess with ceftobiprole supported by the measurement of drug levels in the cerebrospinal fluid
© 2024 The Authors..
In this paper, we describe the case of a patient admitted to our hospital because of a brain abscess due to Streptococcus intermedius. The management of brain abscess is challenging given the limited potential drug options with effective penetration into both the central nervous system and the abscess capsule to achieve adequate therapeutic concentrations. Due to the high anti-streptococcal activity of ceftobiprole and the availability of ceftobiprole therapeutic drug monitoring in our hospital, we decided to treat the patient with ceftobiprole. To maximize the antimicrobial effect of ceftobiprole, we chose a prolonged intravenous infusion, and we monitored its concentrations in both plasma and cerebrospinal fluid.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Heliyon - 10(2024), 6 vom: 30. März, Seite e27285 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Giuliano, Simone [VerfasserIn] |
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| Links: |
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| Themen: |
Brain abscess |
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| Anmerkungen: |
Date Revised 23.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.heliyon.2024.e27285 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370052749 |
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| 100 | 1 | |a Giuliano, Simone |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A case report of treatment of a streptococcal brain abscess with ceftobiprole supported by the measurement of drug levels in the cerebrospinal fluid |
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| 500 | |a Date Revised 23.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024 The Authors. | ||
| 520 | |a In this paper, we describe the case of a patient admitted to our hospital because of a brain abscess due to Streptococcus intermedius. The management of brain abscess is challenging given the limited potential drug options with effective penetration into both the central nervous system and the abscess capsule to achieve adequate therapeutic concentrations. Due to the high anti-streptococcal activity of ceftobiprole and the availability of ceftobiprole therapeutic drug monitoring in our hospital, we decided to treat the patient with ceftobiprole. To maximize the antimicrobial effect of ceftobiprole, we chose a prolonged intravenous infusion, and we monitored its concentrations in both plasma and cerebrospinal fluid | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Brain abscess | |
| 650 | 4 | |a CNS | |
| 650 | 4 | |a CSF | |
| 650 | 4 | |a CSF/blood penetration | |
| 650 | 4 | |a Ceftobiprole | |
| 650 | 4 | |a Meningitis | |
| 650 | 4 | |a Pharmacodynamic | |
| 650 | 4 | |a Pharmacokinetic | |
| 650 | 4 | |a Streptococcus | |
| 650 | 4 | |a Streptococcus intermedius | |
| 650 | 4 | |a Therapeutic drug monitoring | |
| 700 | 1 | |a Angelini, Jacopo |e verfasserin |4 aut | |
| 700 | 1 | |a Flammini, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Della Siega, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Vania, Eleonora |e verfasserin |4 aut | |
| 700 | 1 | |a Montanari, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a D'Elia, Denise |e verfasserin |4 aut | |
| 700 | 1 | |a Biasizzo, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Pagotto, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Tascini, Carlo |e verfasserin |4 aut | |
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