Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus : a multicenter retrospective study
© 2024. The Author(s)..
Clinical implication of a single abnormal value (SAV) in the 100 g oral glucose tolerance test during pregnancy has not been established. We aimed to evaluate the risk of postpartum type 2 diabetes mellitus (T2DM) and investigate adverse pregnancy outcomes in women with SAV, using a retrospective database, from seven medical centers of Korea. Based on the Carpenter-Coustan criteria using two-step approach, pregnancy and postpartum outcomes were compared, among normoglycemic, SAV, and gestational diabetes mellitus (GDM) groups. Among 9353 women, 342 (3.66%) and 418(4.47%) women were included in SAV and GDM groups, respectively. SAV and GDM groups showed significantly higher rates of postpartum T2DM than normoglycemic group (7.60%, 14.83%, and 1.82%, respectively, p < 0.001). And SAV group showed significantly higher rates of pregnancy associated hypertension, preterm birth, and neonatal hypoglycemia and sepsis, compared to normoglycemic group (neonatal sepsis, p = 0.008; the others, p < 0.001). In multivariate analysis, postpartum T2DM was associated with SAV, GDM (with/without insulin), nulliparity, pre-pregnancy BMI, chronic hypertension, hyperlipidemia, and DM family history. A scoring model to predict postpartum T2DM within 5 years, achieved an area under the curve of 0.74. This study demonstrated that not only GDM, but also SAV is a significant risk factor for postpartum T2DM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Scientific reports - 14(2024), 1 vom: 21. März, Seite 6792 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Seon Ui [VerfasserIn] |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 05.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-024-57535-8 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370043936 |
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| 520 | |a Clinical implication of a single abnormal value (SAV) in the 100 g oral glucose tolerance test during pregnancy has not been established. We aimed to evaluate the risk of postpartum type 2 diabetes mellitus (T2DM) and investigate adverse pregnancy outcomes in women with SAV, using a retrospective database, from seven medical centers of Korea. Based on the Carpenter-Coustan criteria using two-step approach, pregnancy and postpartum outcomes were compared, among normoglycemic, SAV, and gestational diabetes mellitus (GDM) groups. Among 9353 women, 342 (3.66%) and 418(4.47%) women were included in SAV and GDM groups, respectively. SAV and GDM groups showed significantly higher rates of postpartum T2DM than normoglycemic group (7.60%, 14.83%, and 1.82%, respectively, p < 0.001). And SAV group showed significantly higher rates of pregnancy associated hypertension, preterm birth, and neonatal hypoglycemia and sepsis, compared to normoglycemic group (neonatal sepsis, p = 0.008; the others, p < 0.001). In multivariate analysis, postpartum T2DM was associated with SAV, GDM (with/without insulin), nulliparity, pre-pregnancy BMI, chronic hypertension, hyperlipidemia, and DM family history. A scoring model to predict postpartum T2DM within 5 years, achieved an area under the curve of 0.74. This study demonstrated that not only GDM, but also SAV is a significant risk factor for postpartum T2DM | ||
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| 700 | 1 | |a Kim, Su Mi |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Jae Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Kil, Ki Cheol |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yeon Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Wie, Jeong Ha |e verfasserin |4 aut | |
| 700 | 1 | |a Jo, Yun Sung |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, Hyun Sun |e verfasserin |4 aut | |
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