N-benzyl-N-methyldecan-1-amine, derived from garlic, and its derivative alleviate 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice
© 2024. The Author(s)..
Given the intricate etiology and pathogenesis of atopic dermatitis (AD), the complete cure of AD remains challenging. This study aimed to investigate if topically applying N-benzyl-N-methyldecan-1-amine (BMDA), derived from garlic, and its derivative [decyl-(4-methoxy-benzyl)-methyl-1-amine] (DMMA) could effectively alleviate AD-like skin lesions in 2,4-dinitrochlorobenzene (DNCB)-treated mice. Administering these compounds to the irritated skin of DNCB-treated mice significantly reduced swelling, rash, and excoriation severity, alongside a corresponding decrease in inflamed epidermis and dermis. Moreover, they inhibited spleen and lymph node enlargement and showed fewer infiltrated mast cells in the epidermis and dermis through toluidine-blue staining. Additionally, they led to a lower IgE titer in mouse sera as determined by ELISA, compared to vehicle treatment. Analyzing skin tissue from the mice revealed decreased transcript levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6), IL-4, iNOS, and COX-2, compared to control mice. Simultaneously, the compounds impeded the activation of inflammation-related signaling molecules such as JNK, p38 MAPK, and NF-κB in the mouse skin. In summary, these findings suggest that BMDA and DMMA hold the potential to be developed as a novel treatment for healing inflammatory AD.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Scientific reports - 14(2024), 1 vom: 21. März, Seite 6776 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Kim, Ji Eun [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.1038/s41598-024-56496-2 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM370042840 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM370042840 | ||
003 | DE-627 | ||
005 | 20240325235416.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240323s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1038/s41598-024-56496-2 |2 doi | |
028 | 5 | 2 | |a pubmed24n1347.xml |
035 | |a (DE-627)NLM370042840 | ||
035 | |a (NLM)38514712 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Kim, Ji Eun |e verfasserin |4 aut | |
245 | 1 | 0 | |a N-benzyl-N-methyldecan-1-amine, derived from garlic, and its derivative alleviate 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 25.03.2024 | ||
500 | |a Date Revised 25.03.2024 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024. The Author(s). | ||
520 | |a Given the intricate etiology and pathogenesis of atopic dermatitis (AD), the complete cure of AD remains challenging. This study aimed to investigate if topically applying N-benzyl-N-methyldecan-1-amine (BMDA), derived from garlic, and its derivative [decyl-(4-methoxy-benzyl)-methyl-1-amine] (DMMA) could effectively alleviate AD-like skin lesions in 2,4-dinitrochlorobenzene (DNCB)-treated mice. Administering these compounds to the irritated skin of DNCB-treated mice significantly reduced swelling, rash, and excoriation severity, alongside a corresponding decrease in inflamed epidermis and dermis. Moreover, they inhibited spleen and lymph node enlargement and showed fewer infiltrated mast cells in the epidermis and dermis through toluidine-blue staining. Additionally, they led to a lower IgE titer in mouse sera as determined by ELISA, compared to vehicle treatment. Analyzing skin tissue from the mice revealed decreased transcript levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6), IL-4, iNOS, and COX-2, compared to control mice. Simultaneously, the compounds impeded the activation of inflammation-related signaling molecules such as JNK, p38 MAPK, and NF-κB in the mouse skin. In summary, these findings suggest that BMDA and DMMA hold the potential to be developed as a novel treatment for healing inflammatory AD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a 2,4-Dinitrochlorobenzene | |
650 | 4 | |a Atopic dermatitis | |
650 | 4 | |a IgE titer | |
650 | 4 | |a Inflammation | |
650 | 4 | |a Mast cells | |
650 | 4 | |a N-benzyl-N-methyldecan-1-amine | |
650 | 7 | |a Dinitrochlorobenzene |2 NLM | |
650 | 7 | |a N-benzyl-N-methyl-dodecan-1-amine |2 NLM | |
650 | 7 | |a 2,3-dimethylmaleic anhydride |2 NLM | |
650 | 7 | |a 6PP3N541QA |2 NLM | |
650 | 7 | |a Cytokines |2 NLM | |
650 | 7 | |a Amines |2 NLM | |
650 | 7 | |a NF-kappa B |2 NLM | |
650 | 7 | |a Maleic Anhydrides |2 NLM | |
700 | 1 | |a Budluang, Phatcharaporn |e verfasserin |4 aut | |
700 | 1 | |a Park, Jumin |e verfasserin |4 aut | |
700 | 1 | |a Lee, Kon Ho |e verfasserin |4 aut | |
700 | 1 | |a Pakdeepromma, Sirichatnach |e verfasserin |4 aut | |
700 | 1 | |a Kaewpiboon, Chutima |e verfasserin |4 aut | |
700 | 1 | |a Kang, Ho Young |e verfasserin |4 aut | |
700 | 1 | |a Hwang, Dae Youn |e verfasserin |4 aut | |
700 | 1 | |a Chung, Young-Hwa |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Scientific reports |d 2011 |g 14(2024), 1 vom: 21. März, Seite 6776 |w (DE-627)NLM215703936 |x 2045-2322 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2024 |g number:1 |g day:21 |g month:03 |g pages:6776 |
856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-024-56496-2 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2024 |e 1 |b 21 |c 03 |h 6776 |