Traceability of chemicals from Tripterygium Wilfordii Hook. f. in raw honey and the potential synergistic effects of honey on acute toxicity induced by celastrol and triptolide
Copyright © 2024 Elsevier Ltd. All rights reserved..
The object of this study was to trace TwHf-derived toxins in raw honey and clarify their acute toxic effect related to the addition of honey or sugars. TwHf flowers, raw honey from TwHf planting base and from beekeepers in high-risk area were detected using LC-MS/MS. The results revealed five target toxins were detected in TwHf flowers; only celastrol was detected in one raw honey sample, as a food safety risk factor, celastrol had been traced back to TwHf flowers from raw honey. In a series of acute toxic tests on zebrafish, toxification effects were observed when honey, mimic honey or sugar was mixed with toxins. The degree of toxicity varied among various sugar-based solutions. At the same mass concentration, they follow this order: raw honey/mimic honey > glucose > fructose. The main toxic target organs of triptolide and celastrol with honey were the heart and liver.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:447 |
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| Enthalten in: |
Food chemistry - 447(2024) vom: 30. Apr., Seite 139044 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xiao, Tian [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.04.2024 Date Revised 10.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.foodchem.2024.139044 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370030559 |
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| 100 | 1 | |a Xiao, Tian |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Traceability of chemicals from Tripterygium Wilfordii Hook. f. in raw honey and the potential synergistic effects of honey on acute toxicity induced by celastrol and triptolide |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 10.04.2024 | ||
| 500 | |a Date Revised 10.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier Ltd. All rights reserved. | ||
| 520 | |a The object of this study was to trace TwHf-derived toxins in raw honey and clarify their acute toxic effect related to the addition of honey or sugars. TwHf flowers, raw honey from TwHf planting base and from beekeepers in high-risk area were detected using LC-MS/MS. The results revealed five target toxins were detected in TwHf flowers; only celastrol was detected in one raw honey sample, as a food safety risk factor, celastrol had been traced back to TwHf flowers from raw honey. In a series of acute toxic tests on zebrafish, toxification effects were observed when honey, mimic honey or sugar was mixed with toxins. The degree of toxicity varied among various sugar-based solutions. At the same mass concentration, they follow this order: raw honey/mimic honey > glucose > fructose. The main toxic target organs of triptolide and celastrol with honey were the heart and liver | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Acute toxicity | |
| 650 | 4 | |a Carboxymethylcellulose sodium (PubChem CID: 6328154) | |
| 650 | 4 | |a Celastrol (PubChem CID: 122724) | |
| 650 | 4 | |a DMSO (PubChem CID: 679) | |
| 650 | 4 | |a Honey | |
| 650 | 4 | |a LC-MS/MS | |
| 650 | 4 | |a NADES | |
| 650 | 4 | |a Toxification effect | |
| 650 | 4 | |a Tricaine methanesulfonate (PubChem CID: 261501) | |
| 650 | 4 | |a Tripterygium wilfordii Hook. f. | |
| 650 | 4 | |a Triptolide (PubChem CID: 107985) | |
| 650 | 4 | |a Wilforgine (PubChem CID: 124030) | |
| 650 | 4 | |a Wilfortrine (PubChem CID: 73321) | |
| 650 | 4 | |a wilforine (PubChem CID: 601100) | |
| 650 | 7 | |a triptolide |2 NLM | |
| 650 | 7 | |a 19ALD1S53J |2 NLM | |
| 650 | 7 | |a celastrol |2 NLM | |
| 650 | 7 | |a L8GG98663L |2 NLM | |
| 650 | 7 | |a Sugars |2 NLM | |
| 650 | 7 | |a Diterpenes |2 NLM | |
| 650 | 7 | |a Epoxy Compounds |2 NLM | |
| 650 | 7 | |a Phenanthrenes |2 NLM | |
| 650 | 7 | |a Pentacyclic Triterpenes |2 NLM | |
| 700 | 1 | |a Yang, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Guang |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Xiue |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Xiaoying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Xiaohong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yajie |e verfasserin |4 aut | |
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