Alcohol-alcohol cross-coupling enabled by SH2 radical sorting
Alcohols represent a functional group class with unparalleled abundance and structural diversity. In an era of chemical synthesis that prioritizes reducing time to target and maximizing exploration of chemical space, harnessing these building blocks for carbon-carbon bond-forming reactions is a key goal in organic chemistry. In particular, leveraging a single activation mode to form a new C(sp3)-C(sp3) bond from two alcohol subunits would enable access to an extraordinary level of structural diversity. In this work, we report a nickel radical sorting-mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to air.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:383 |
|---|---|
| Enthalten in: |
Science (New York, N.Y.) - 383(2024), 6689 vom: 22. März, Seite 1350-1357 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chen, Ruizhe [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 21.03.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1126/science.adl5890 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370026136 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370026136 | ||
| 003 | DE-627 | ||
| 005 | 20240323001805.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240323s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/science.adl5890 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1341.xml |
| 035 | |a (DE-627)NLM370026136 | ||
| 035 | |a (NLM)38513032 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chen, Ruizhe |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Alcohol-alcohol cross-coupling enabled by SH2 radical sorting |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 21.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Alcohols represent a functional group class with unparalleled abundance and structural diversity. In an era of chemical synthesis that prioritizes reducing time to target and maximizing exploration of chemical space, harnessing these building blocks for carbon-carbon bond-forming reactions is a key goal in organic chemistry. In particular, leveraging a single activation mode to form a new C(sp3)-C(sp3) bond from two alcohol subunits would enable access to an extraordinary level of structural diversity. In this work, we report a nickel radical sorting-mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to air | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Intermaggio, Nicholas E |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Jiaxin |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi-Ashton, James A |e verfasserin |4 aut | |
| 700 | 1 | |a Gould, Colin A |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Robert T |e verfasserin |4 aut | |
| 700 | 1 | |a Alcázar, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a MacMillan, David W C |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science (New York, N.Y.) |d 1880 |g 383(2024), 6689 vom: 22. März, Seite 1350-1357 |w (DE-627)NLM000023450 |x 1095-9203 |7 nnns |
| 773 | 1 | 8 | |g volume:383 |g year:2024 |g number:6689 |g day:22 |g month:03 |g pages:1350-1357 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1126/science.adl5890 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 383 |j 2024 |e 6689 |b 22 |c 03 |h 1350-1357 | ||