Repeated co-option of HMG-box genes for sex determination in brown algae and animals
In many eukaryotes, genetic sex determination is not governed by XX/XY or ZW/ZZ systems but by a specialized region on the poorly studied U (female) or V (male) sex chromosomes. Previous studies have hinted at the existence of a dominant male-sex factor on the V chromosome in brown algae, a group of multicellular eukaryotes distantly related to animals and plants. The nature of this factor has remained elusive. Here, we demonstrate that an HMG-box gene acts as the male-determining factor in brown algae, mirroring the role HMG-box genes play in sex determination in animals. Over a billion-year evolutionary timeline, these lineages have independently co-opted the HMG box for male determination, representing a paradigm for evolution's ability to recurrently use the same genetic "toolkit" to accomplish similar tasks.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:383 |
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| Enthalten in: |
Science (New York, N.Y.) - 383(2024), 6689 vom: 22. März, Seite eadk5466 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Luthringer, Rémy [VerfasserIn] |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1126/science.adk5466 |
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| funding: |
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| PPN (Katalog-ID): |
NLM370026047 |
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| 520 | |a In many eukaryotes, genetic sex determination is not governed by XX/XY or ZW/ZZ systems but by a specialized region on the poorly studied U (female) or V (male) sex chromosomes. Previous studies have hinted at the existence of a dominant male-sex factor on the V chromosome in brown algae, a group of multicellular eukaryotes distantly related to animals and plants. The nature of this factor has remained elusive. Here, we demonstrate that an HMG-box gene acts as the male-determining factor in brown algae, mirroring the role HMG-box genes play in sex determination in animals. Over a billion-year evolutionary timeline, these lineages have independently co-opted the HMG box for male determination, representing a paradigm for evolution's ability to recurrently use the same genetic "toolkit" to accomplish similar tasks | ||
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| 700 | 1 | |a Guerra, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Colin, Sébastien |e verfasserin |4 aut | |
| 700 | 1 | |a Martinho, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Hoshino, Masakazu |e verfasserin |4 aut | |
| 700 | 1 | |a Badis, Yacine |e verfasserin |4 aut | |
| 700 | 1 | |a Lipinska, Agnieszka P |e verfasserin |4 aut | |
| 700 | 1 | |a Haas, Fabian B |e verfasserin |4 aut | |
| 700 | 1 | |a Barrera-Redondo, Josué |e verfasserin |4 aut | |
| 700 | 1 | |a Alva, Vikram |e verfasserin |4 aut | |
| 700 | 1 | |a Coelho, Susana M |e verfasserin |4 aut | |
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