Identification and bioactivity evaluation of ring-opening and lactone forms of enterolactone from sheep fed flaxseed cake
The previously undescribed lactone ring-opening enterolactone and its sulphate were purified along with the lactone counterparts from the urine of dairy sheep fed flaxseed cake. The structures were determined by NMR and MS analyses. The ring-opening and lactone forms underwent mutual transformation with changes in pH and milk could protect the lactone form. Enterolactone exhibited more effective anti-proliferation activity on MDA-MB-231 breast cancer cells than its ring-opening counterpart, while the ring-opening enterolactone demonstrated more effective anti-osteoporosis activity than the lactone form. The results indicated the potential for targeting biological functions through pH and medium manipulation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Natural product research - (2024) vom: 21. März, Seite 1-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhuang, Cong-Cong [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-osteoporosis |
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| Anmerkungen: |
Date Revised 21.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1080/14786419.2024.2331606 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370010108 |
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| 100 | 1 | |a Zhuang, Cong-Cong |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Identification and bioactivity evaluation of ring-opening and lactone forms of enterolactone from sheep fed flaxseed cake |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 21.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a The previously undescribed lactone ring-opening enterolactone and its sulphate were purified along with the lactone counterparts from the urine of dairy sheep fed flaxseed cake. The structures were determined by NMR and MS analyses. The ring-opening and lactone forms underwent mutual transformation with changes in pH and milk could protect the lactone form. Enterolactone exhibited more effective anti-proliferation activity on MDA-MB-231 breast cancer cells than its ring-opening counterpart, while the ring-opening enterolactone demonstrated more effective anti-osteoporosis activity than the lactone form. The results indicated the potential for targeting biological functions through pH and medium manipulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Mammalian lignan | |
| 650 | 4 | |a anti-osteoporosis | |
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a pH dependent structure | |
| 650 | 4 | |a ring-opening enterolactone | |
| 700 | 1 | |a Liu, Chun-Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Hai-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xin-Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Dan-Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Zhong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Li-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Chao-Mei |e verfasserin |4 aut | |
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