Noninvasive Stereotactic Radiotherapy for PADN in an Acute Canine Model of Pulmonary Arterial Hypertension
© 2024 The Authors..
This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted in reduced mean pulmonary artery pressure, pulmonary capillary wedge pressure, and pulmonary vascular resistance, and insignificantly increased cardiac output. In comparison to the control group, serum norepinephrine levels at 1 month and 6 months were significantly lower in the CyberKnife group. Computed tomography, pulmonary angiography, and histology analysis revealed that SBRT was associated with minimal collateral damage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
JACC. Basic to translational science - 9(2024), 2 vom: 15. Feb., Seite 244-256 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xu, Wei [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Revised 22.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.jacbts.2023.09.013 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370003020 |
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| 520 | |a This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted in reduced mean pulmonary artery pressure, pulmonary capillary wedge pressure, and pulmonary vascular resistance, and insignificantly increased cardiac output. In comparison to the control group, serum norepinephrine levels at 1 month and 6 months were significantly lower in the CyberKnife group. Computed tomography, pulmonary angiography, and histology analysis revealed that SBRT was associated with minimal collateral damage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a noninvasive stereotactic body radiotherapy | |
| 650 | 4 | |a pulmonary arterial hypertension | |
| 650 | 4 | |a pulmonary artery | |
| 650 | 4 | |a pulmonary artery denervation | |
| 700 | 1 | |a Wang, Ding-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zi-Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Yi-Lun |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Dang-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Song |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Xin-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Yong-Tai |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Da-Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yue |e verfasserin |4 aut | |
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