Quantitative proteome dynamics across embryogenesis in a model chordate
© 2024 The Author(s)..
The evolution of gene expression programs underlying the development of vertebrates remains poorly characterized. Here, we present a comprehensive proteome atlas of the model chordate Ciona, covering eight developmental stages and ∼7,000 translated genes, accompanied by a multi-omics analysis of co-evolution with the vertebrate Xenopus. Quantitative proteome comparisons argue against the widely held hourglass model, based solely on transcriptomic profiles, whereby peak conservation is observed during mid-developmental stages. Our analysis reveals maximal divergence at these stages, particularly gastrulation and neurulation. Together, our work provides a valuable resource for evaluating conservation and divergence of multi-omics profiles underlying the diversification of vertebrates.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
iScience - 27(2024), 4 vom: 19. März, Seite 109355 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Frese, Alexander N [VerfasserIn] |
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| Links: |
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| Themen: |
Animals |
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| Anmerkungen: |
Date Revised 22.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.isci.2024.109355 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369997069 |
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| 520 | |a © 2024 The Author(s). | ||
| 520 | |a The evolution of gene expression programs underlying the development of vertebrates remains poorly characterized. Here, we present a comprehensive proteome atlas of the model chordate Ciona, covering eight developmental stages and ∼7,000 translated genes, accompanied by a multi-omics analysis of co-evolution with the vertebrate Xenopus. Quantitative proteome comparisons argue against the widely held hourglass model, based solely on transcriptomic profiles, whereby peak conservation is observed during mid-developmental stages. Our analysis reveals maximal divergence at these stages, particularly gastrulation and neurulation. Together, our work provides a valuable resource for evaluating conservation and divergence of multi-omics profiles underlying the diversification of vertebrates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Embryology | |
| 650 | 4 | |a Evolutionary developmental biology | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a Transcriptomics | |
| 700 | 1 | |a Mariossi, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Levine, Michael S |e verfasserin |4 aut | |
| 700 | 1 | |a Wühr, Martin |e verfasserin |4 aut | |
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