Biosensors; a novel concept in real-time detection of autophagy
Copyright © 2024 Elsevier B.V. All rights reserved..
Autophagy is an early-stage response with self-degradation properties against several insulting conditions. To date, the critical role of autophagy has been well-documented in physiological and pathological conditions. This process involves various signaling and functional biomolecules, which are involved in different steps of the autophagic response. During recent decades, a range of biochemical analyses, chemical assays, and varied imaging techniques have been used for monitoring this pathway. Due to the complexity and dynamic aspects of autophagy, the application of the conventional methodology for following autophagic progression is frequently associated with a mistake in discrimination between a complete and incomplete autophagic response. Biosensors provide a de novo platform for precise and accurate analysis of target molecules in different biological settings. It has been suggested that these devices are applicable for real-time monitoring and highly sensitive detection of autophagy effectors. In this review article, we focus on cutting-edge biosensing technologies associated with autophagy detection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:254 |
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| Enthalten in: |
Biosensors & bioelectronics - 254(2024) vom: 15. Apr., Seite 116204 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nasrollahpour, Hassan [VerfasserIn] |
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| Links: |
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| Themen: |
Autophagy |
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| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 01.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bios.2024.116204 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Autophagy is an early-stage response with self-degradation properties against several insulting conditions. To date, the critical role of autophagy has been well-documented in physiological and pathological conditions. This process involves various signaling and functional biomolecules, which are involved in different steps of the autophagic response. During recent decades, a range of biochemical analyses, chemical assays, and varied imaging techniques have been used for monitoring this pathway. Due to the complexity and dynamic aspects of autophagy, the application of the conventional methodology for following autophagic progression is frequently associated with a mistake in discrimination between a complete and incomplete autophagic response. Biosensors provide a de novo platform for precise and accurate analysis of target molecules in different biological settings. It has been suggested that these devices are applicable for real-time monitoring and highly sensitive detection of autophagy effectors. In this review article, we focus on cutting-edge biosensing technologies associated with autophagy detection | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Autophagy | |
| 650 | 4 | |a Biosensors | |
| 650 | 4 | |a Real-time and sensitive detection | |
| 650 | 4 | |a Theranostics | |
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| 700 | 1 | |a Sharifi, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Rezabakhsh, Aysa |e verfasserin |4 aut | |
| 700 | 1 | |a Khalilzadeh, Balal |e verfasserin |4 aut | |
| 700 | 1 | |a Rahbarghazi, Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Yousefi, Hadi |e verfasserin |4 aut | |
| 700 | 1 | |a Klionsky, Daniel J |e verfasserin |4 aut | |
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