An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironment
Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved..
BACKGROUND: Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the landscape of these activities at the pan-cancer level is still lacking.
METHODS: We proposed a computational approach for quantifying DR-related molecular activities and delineating the landscape of these activities across 33 cancer types and 30 normal tissues within 27,320 samples. We thoroughly examined the associations between DR-related molecular activities and various factors, including the tumour microenvironment, immunological phenotypes, genomic features, and clinical prognosis. Meanwhile, we identified two DR genes that show potential as prognostic predictors in hepatocellular carcinoma and verified them by immunohistochemical assays in 90 patients.
FINDINGS: We found that DR-related molecular activities showed a close association with tumour immunity and hold potential for predicting immunotherapy responses in various cancers. Importantly, a higher level of DR-related molecular activities is associated with improved overall survival and cancer-specific survival. FZD1 and G6PD are two DR genes that serve as biomarkers for predicting the prognosis of patients with hepatocellular carcinoma.
INTERPRETATION: This study presents a robust link between DR-related molecular activities and tumour immunity across multiple cancer types. Our research could open the path for further investigation of DR-related molecular processes in cancer treatment.
FUNDING: National Natural Science Foundation of China (Grant No. 82000628) and the Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province (Grant No. 2023LSYS001).
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
---|---|
Enthalten in: |
EBioMedicine - 102(2024) vom: 23. Apr., Seite 105078 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Song, Xiaoyi [VerfasserIn] |
---|
Links: |
---|
Themen: |
Caloric restriction |
---|
Anmerkungen: |
Date Completed 15.04.2024 Date Revised 15.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.ebiom.2024.105078 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369974603 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369974603 | ||
003 | DE-627 | ||
005 | 20240415233503.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240322s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.ebiom.2024.105078 |2 doi | |
028 | 5 | 2 | |a pubmed24n1376.xml |
035 | |a (DE-627)NLM369974603 | ||
035 | |a (NLM)38507875 | ||
035 | |a (PII)S2352-3964(24)00113-0 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Song, Xiaoyi |e verfasserin |4 aut | |
245 | 1 | 3 | |a An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironment |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 15.04.2024 | ||
500 | |a Date Revised 15.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved. | ||
520 | |a BACKGROUND: Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the landscape of these activities at the pan-cancer level is still lacking | ||
520 | |a METHODS: We proposed a computational approach for quantifying DR-related molecular activities and delineating the landscape of these activities across 33 cancer types and 30 normal tissues within 27,320 samples. We thoroughly examined the associations between DR-related molecular activities and various factors, including the tumour microenvironment, immunological phenotypes, genomic features, and clinical prognosis. Meanwhile, we identified two DR genes that show potential as prognostic predictors in hepatocellular carcinoma and verified them by immunohistochemical assays in 90 patients | ||
520 | |a FINDINGS: We found that DR-related molecular activities showed a close association with tumour immunity and hold potential for predicting immunotherapy responses in various cancers. Importantly, a higher level of DR-related molecular activities is associated with improved overall survival and cancer-specific survival. FZD1 and G6PD are two DR genes that serve as biomarkers for predicting the prognosis of patients with hepatocellular carcinoma | ||
520 | |a INTERPRETATION: This study presents a robust link between DR-related molecular activities and tumour immunity across multiple cancer types. Our research could open the path for further investigation of DR-related molecular processes in cancer treatment | ||
520 | |a FUNDING: National Natural Science Foundation of China (Grant No. 82000628) and the Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province (Grant No. 2023LSYS001) | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Caloric restriction | |
650 | 4 | |a Dietary restriction | |
650 | 4 | |a Immunotherapy | |
650 | 4 | |a Pan-cancer | |
650 | 4 | |a Single-cell transcriptome | |
700 | 1 | |a Wei, Jiaxing |e verfasserin |4 aut | |
700 | 1 | |a Li, Yang |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Wen |e verfasserin |4 aut | |
700 | 1 | |a Cai, Zhiyuan |e verfasserin |4 aut | |
700 | 1 | |a Li, Kunwei |e verfasserin |4 aut | |
700 | 1 | |a Wei, Jingyue |e verfasserin |4 aut | |
700 | 1 | |a Lu, Jieyu |e verfasserin |4 aut | |
700 | 1 | |a Pan, Wanping |e verfasserin |4 aut | |
700 | 1 | |a Li, Man |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t EBioMedicine |d 2014 |g 102(2024) vom: 23. Apr., Seite 105078 |w (DE-627)NLM244581355 |x 2352-3964 |7 nnns |
773 | 1 | 8 | |g volume:102 |g year:2024 |g day:23 |g month:04 |g pages:105078 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ebiom.2024.105078 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 102 |j 2024 |b 23 |c 04 |h 105078 |