Involvement of Lipids and Lipid Mediators in Inflammation and Atherogenesis

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Atherosclerosis is the pathophysiological basis for major diseases, such as coronary heart disease, cerebral stroke, and peripheral arterial disease, which have become epidemic in modern Western society. Atherosclerosis has a complex nature that involves mutually related immune and metabolic mechanisms. Many cells of the vascular wall and peripheral bloodstream, including endothelial cells, monocytes and macrophages, platelets, and others, are involved in the development and progression of atherosclerosis. These cells perform a number of innate immune functions, disorders of which are associated with atherosclerosis. Furthermore, lipids are not only a morphological substrate but also important participants in the development of atherosclerosis. They are involved in the development and resolution of inflammation and mediate vascular cell function.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - year:2024

Enthalten in:

Current medicinal chemistry - (2024) vom: 19. März

Sprache:

Englisch

Beteiligte Personen:

Kotlyarov, Stanislav [VerfasserIn]

Links:

Volltext

Themen:

Atherosclerosis
Inflammation
Innate immune system
Journal Article
Lipids
Macrophages
Platelets

Anmerkungen:

Date Revised 20.03.2024

published: Print-Electronic

Citation Status Publisher

doi:

10.2174/0109298673303369240312092913

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM369941705