Status of vitamins and minerals in children with screening-identified celiac disease : A case-control study
© 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition..
OBJECTIVES: Micronutrient deficiencies characterize classical "late-diagnosed" celiac disease (CeD). This study aimed to identify the prevalence of micronutrient deficiencies among children with "early-diagnosed" screening-identified CeD to determine the clinical value of routine testing for deficiencies in those patients.
METHODS: A case-control study was conducted on screening-identified CeD patients diagnosed during a mass screening study (84 patients, mean age 11.3 ± 2.6 years). The controls (443 children, mean age 10.8 ± 2.5 years) were negative for celiac disease serological screening. Hemoglobin, serum levels of iron, ferritin, folate, vitamin B12, vitamin A, vitamin E, 25-OH vitamin D, zinc, and selenium were measured.
RESULTS: The mean serum levels of hemoglobin, iron, ferritin, vitamin D, zinc, copper, and selenium were significantly lower in CeD patients than in healthy controls (hemoglobin 12.56 vs. 13.02 g/dL [p = 0.04]; iron 10.61 vs. 17.6 µmol/L [p < 0.001], ferritin 25.7 vs. 48.3 µg/L [p < 0.001], vitamin D 29.1 vs. 37.5 nmol/L, zinc 11.9 vs. 21.7 µmol/L, copper 18.9 vs. 32.5 µmol/L, selenium 1.04 vs. 1.36 µmol/L; p < 0.001). Patients with celiac and severe intestinal damage (Marsh IIIb and IIIc) had significantly lower serum ferritin and vitamin A levels than patients with mild intestinal damage (Marsh II and IIIa) (ferritin 15 vs. 22 µg/L, p < 0.025; vitamin A 0.85 vs. 1.35 µmol/L, p = 0.007).
CONCLUSION: Micronutrient deficiencies are still detectable in "early-diagnosed" screening-identified CeD cases, a clinically relevant result that strongly supports efforts for screening and early diagnosis of CeD.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
---|---|
Enthalten in: |
Journal of pediatric gastroenterology and nutrition - 78(2024), 3 vom: 20. März, Seite 677-684 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Al-Hussaini, Abdulrahman [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 21.03.2024 Date Revised 21.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1002/jpn3.12126 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369939948 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369939948 | ||
003 | DE-627 | ||
005 | 20240322000906.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240320s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/jpn3.12126 |2 doi | |
028 | 5 | 2 | |a pubmed24n1339.xml |
035 | |a (DE-627)NLM369939948 | ||
035 | |a (NLM)38504391 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Al-Hussaini, Abdulrahman |e verfasserin |4 aut | |
245 | 1 | 0 | |a Status of vitamins and minerals in children with screening-identified celiac disease |b A case-control study |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.03.2024 | ||
500 | |a Date Revised 21.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. | ||
520 | |a OBJECTIVES: Micronutrient deficiencies characterize classical "late-diagnosed" celiac disease (CeD). This study aimed to identify the prevalence of micronutrient deficiencies among children with "early-diagnosed" screening-identified CeD to determine the clinical value of routine testing for deficiencies in those patients | ||
520 | |a METHODS: A case-control study was conducted on screening-identified CeD patients diagnosed during a mass screening study (84 patients, mean age 11.3 ± 2.6 years). The controls (443 children, mean age 10.8 ± 2.5 years) were negative for celiac disease serological screening. Hemoglobin, serum levels of iron, ferritin, folate, vitamin B12, vitamin A, vitamin E, 25-OH vitamin D, zinc, and selenium were measured | ||
520 | |a RESULTS: The mean serum levels of hemoglobin, iron, ferritin, vitamin D, zinc, copper, and selenium were significantly lower in CeD patients than in healthy controls (hemoglobin 12.56 vs. 13.02 g/dL [p = 0.04]; iron 10.61 vs. 17.6 µmol/L [p < 0.001], ferritin 25.7 vs. 48.3 µg/L [p < 0.001], vitamin D 29.1 vs. 37.5 nmol/L, zinc 11.9 vs. 21.7 µmol/L, copper 18.9 vs. 32.5 µmol/L, selenium 1.04 vs. 1.36 µmol/L; p < 0.001). Patients with celiac and severe intestinal damage (Marsh IIIb and IIIc) had significantly lower serum ferritin and vitamin A levels than patients with mild intestinal damage (Marsh II and IIIa) (ferritin 15 vs. 22 µg/L, p < 0.025; vitamin A 0.85 vs. 1.35 µmol/L, p = 0.007) | ||
520 | |a CONCLUSION: Micronutrient deficiencies are still detectable in "early-diagnosed" screening-identified CeD cases, a clinically relevant result that strongly supports efforts for screening and early diagnosis of CeD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Saudi Arabia | |
650 | 4 | |a gluten free diet | |
650 | 4 | |a micronutrient deficiency | |
650 | 7 | |a Vitamins |2 NLM | |
650 | 7 | |a Vitamin A |2 NLM | |
650 | 7 | |a 11103-57-4 |2 NLM | |
650 | 7 | |a Selenium |2 NLM | |
650 | 7 | |a H6241UJ22B |2 NLM | |
650 | 7 | |a Copper |2 NLM | |
650 | 7 | |a 789U1901C5 |2 NLM | |
650 | 7 | |a Micronutrients |2 NLM | |
650 | 7 | |a Iron |2 NLM | |
650 | 7 | |a E1UOL152H7 |2 NLM | |
650 | 7 | |a Zinc |2 NLM | |
650 | 7 | |a J41CSQ7QDS |2 NLM | |
650 | 7 | |a Vitamin D |2 NLM | |
650 | 7 | |a 1406-16-2 |2 NLM | |
650 | 7 | |a Vitamin K |2 NLM | |
650 | 7 | |a 12001-79-5 |2 NLM | |
650 | 7 | |a Ferritins |2 NLM | |
650 | 7 | |a 9007-73-2 |2 NLM | |
650 | 7 | |a Hemoglobins |2 NLM | |
700 | 1 | |a Troncone, Riccardo |e verfasserin |4 aut | |
700 | 1 | |a Alobaid, Suzan |e verfasserin |4 aut | |
700 | 1 | |a Bashir, Muhammed Salman |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of pediatric gastroenterology and nutrition |d 1982 |g 78(2024), 3 vom: 20. März, Seite 677-684 |w (DE-627)NLM012621927 |x 1536-4801 |7 nnns |
773 | 1 | 8 | |g volume:78 |g year:2024 |g number:3 |g day:20 |g month:03 |g pages:677-684 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/jpn3.12126 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 78 |j 2024 |e 3 |b 20 |c 03 |h 677-684 |