The estimated mediating roles of anemia-related variables in the association between kidney function and mortality : a National Health and Nutrition Examination Survey (NHANES) study
© 2024. The Author(s)..
Anemia is a common complication of chronic kidney disease (CKD), impacting long-term outcomes such as mortality and morbidity. Analyzing NHANES data from 1999 through 2016 for adults aged ≥ 20 years, we assessed the mediating effects of anemia biomarkers (hemoglobin, hematocrit, red cell distribution width [RDW], and mean corpuscular hemoglobin concentration [MCHC]) on CKD-related outcomes by using hazard ratios from a biomarker-adjusted model. Of 44,099 participants, 7463 experienced all-cause death. Cox proportional hazard models revealed a higher all-cause mortality risk in the > 45 years and CKD groups than in the early CKD group. Hemoglobin, hematocrit and MCHC were inversely related to all-cause mortality; RDW was related to mortality. Single mediation analysis showed greater mediating effects of anemia indicators on CKD and mortality in the elderly (> 65 years) population than those in the general population. In the multimediation analysis, the combined mediating effect of anemia was higher in the CKD population than in the general population. This study showed a proportional increase in the mediating effect of anemia with CKD stage, suggesting potential therapeutic avenues. However, further exploration of other mediating factors on kidney outcomes is necessary.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Scientific reports - 14(2024), 1 vom: 19. März, Seite 6621 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Yae Hyun [VerfasserIn] |
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| Links: |
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| Themen: |
Anemia |
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| Anmerkungen: |
Date Completed 21.03.2024 Date Revised 23.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-024-56877-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369933885 |
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| 100 | 1 | |a Kim, Yae Hyun |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The estimated mediating roles of anemia-related variables in the association between kidney function and mortality |b a National Health and Nutrition Examination Survey (NHANES) study |
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| 500 | |a Date Revised 23.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a Anemia is a common complication of chronic kidney disease (CKD), impacting long-term outcomes such as mortality and morbidity. Analyzing NHANES data from 1999 through 2016 for adults aged ≥ 20 years, we assessed the mediating effects of anemia biomarkers (hemoglobin, hematocrit, red cell distribution width [RDW], and mean corpuscular hemoglobin concentration [MCHC]) on CKD-related outcomes by using hazard ratios from a biomarker-adjusted model. Of 44,099 participants, 7463 experienced all-cause death. Cox proportional hazard models revealed a higher all-cause mortality risk in the > 45 years and CKD groups than in the early CKD group. Hemoglobin, hematocrit and MCHC were inversely related to all-cause mortality; RDW was related to mortality. Single mediation analysis showed greater mediating effects of anemia indicators on CKD and mortality in the elderly (> 65 years) population than those in the general population. In the multimediation analysis, the combined mediating effect of anemia was higher in the CKD population than in the general population. This study showed a proportional increase in the mediating effect of anemia with CKD stage, suggesting potential therapeutic avenues. However, further exploration of other mediating factors on kidney outcomes is necessary | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anemia | |
| 650 | 4 | |a Chronic kidney disease | |
| 650 | 4 | |a Mediation analysis | |
| 650 | 4 | |a Mortality | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Hemoglobins |2 NLM | |
| 700 | 1 | |a Lee, Whanhee |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Kyun Young |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yaerim |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, Ara |e verfasserin |4 aut | |
| 700 | 1 | |a Weon, Boram |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jeonghwan |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Wencheng |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Dong Ki |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yon Su |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Chun Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jung Pyo |e verfasserin |4 aut | |
| 700 | 0 | |a Korean Association for the study of Renal Anemia, artificial Intelligence (KARAI) |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Sung Gyun |e investigator |4 oth | |
| 700 | 1 | |a Ko, Gang Jee |e investigator |4 oth | |
| 700 | 1 | |a Park, Jung Tak |e investigator |4 oth | |
| 700 | 1 | |a Chang, Tae Ik |e investigator |4 oth | |
| 700 | 1 | |a Chung, Sungjin |e investigator |4 oth | |
| 700 | 1 | |a Lee, Sang Ho |e investigator |4 oth | |
| 700 | 1 | |a Choi, Bum Soon |e investigator |4 oth | |
| 700 | 1 | |a Jeon, Jin Seok |e investigator |4 oth | |
| 700 | 1 | |a Song, Sangheon |e investigator |4 oth | |
| 700 | 1 | |a Choi, Dae Eun |e investigator |4 oth | |
| 700 | 1 | |a Ryu, Dong-Ryeol |e investigator |4 oth | |
| 700 | 1 | |a Jung, Woo Kyung |e investigator |4 oth | |
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