Controlled and Site-Selective C-H/N-H Alkenylation, Dialkenylation, and Dehydrogenative β-Alkenylation of Various N-Heterocycles
Here, we report controlled and site-selective C-H alkenylation and dialkenylation of indolizines and pyrrolo[1,2-a]quinolines with β-alkoxyvinyl trifluoromethylketones under simple and practical conditions. Moreover, this direct C-H alkenylation strategy can also be extended to imidazo[1,2-a]pyridines. Notably, without a transition metal and external oxidant, efficient dehydrogenative β-alkenylation of tertiary amines with β-alkoxyvinyl trifluoromethylketones is presented.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
The Journal of organic chemistry - 89(2024), 7 vom: 05. Apr., Seite 4840-4850 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yan, Jin [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 05.04.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.joc.4c00064 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369921852 |
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| 100 | 1 | |a Yan, Jin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Controlled and Site-Selective C-H/N-H Alkenylation, Dialkenylation, and Dehydrogenative β-Alkenylation of Various N-Heterocycles |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Here, we report controlled and site-selective C-H alkenylation and dialkenylation of indolizines and pyrrolo[1,2-a]quinolines with β-alkoxyvinyl trifluoromethylketones under simple and practical conditions. Moreover, this direct C-H alkenylation strategy can also be extended to imidazo[1,2-a]pyridines. Notably, without a transition metal and external oxidant, efficient dehydrogenative β-alkenylation of tertiary amines with β-alkoxyvinyl trifluoromethylketones is presented | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Zhong, Suijie |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Yihuan |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Limin |e verfasserin |4 aut | |
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