Influencing factors of futile recanalization after endovascular intervention in patients with acute basilar artery occlusion
OBJECTIVES: To explore the influence factors for futile recanalization following endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO).
METHODS: Clinical data of patients with acute BAO, who underwent endovascular treatment within 24 h of onset from January 2017 to November 2022, were retrospectively analyzed. The futile recanalization was defined as modified Thrombolysis in Cerebral Infarction (mTICI)≥2b or 3 after successful reperfusion, but the modified Rankin Scale score >2 at 90d after EVT. Binary logistic regression model was used to analyze the influencing factors of futile recanalization.
RESULTS: A total of 471 BAO patients with a median age of 68 (57-74) years were included and 68.9% were males, among whom 298 (63.27%) experienced futile recanalization. Multivariate analysis revealed that concomitant atrial fibrillation (OR=0.456, 95%CI: 0.287-0.737, P<0.01), bridging thrombolysis (OR=0.640, 95%CI: 0.416-0.985, P<0.05), achieving mTICI grade 3 (OR=0.554, 95%CI: 0.334-0.918, P<0.05), arterial occlusive lesion (AOL) grade 3 (OR=0.521, 95%CI: 0.326-0.834, P<0.01), and early postoperative statin therapy (OR=0.509, 95%CI: 0.273-0.948, P<0.05) were protective factors for futile recanalization after EVT in acute BAO patients; while high baseline National Institutes of Health Stroke Scale (NIHSS) score (OR=1.068, 95%CI: 1.049-1.087, P<0.01), coexisting hypertension (OR=1.571, 95%CI: 1.017-2.427, P<0.05), multiple retrieval attempts (OR=1.237, 95%CI: 1.029-1.488, P<0.05) and postoperative hemorrhagic transformation (OR=8.497, 95%CI: 2.879-25.076, P<0.01) were risk factors. For TOAST classification, cardiogenic embolism (OR=0.321, 95% CI: 0.193-0.534, P<0.01) and other types (OR=0.499, 95% CI: 0.260-0.961, P<0.05) were also an independent risk factors for futile recanalization after EVT in acute BAO.
CONCLUSIONS: The incidence of futile recanalization after EVT in patients with acute BAO is high. Bridging venous thrombolysis before operation and an early postoperative statin therapy may reduce the incidence of futile recanalization.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - (2024) vom: 18. März, Seite 1-10 |
| Sprache: |
Englisch |
|---|
| Weiterer Titel: |
急性基底动脉闭塞血管内治疗后发生无效再通的影响因素 |
|---|
| Beteiligte Personen: |
Yan, Yi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Basilar artery |
|---|
| Anmerkungen: |
Date Revised 19.03.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.3724/zdxbyxb-2023-0425 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369909380 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369909380 | ||
| 003 | DE-627 | ||
| 005 | 20240319233717.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240319s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3724/zdxbyxb-2023-0425 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1336.xml |
| 035 | |a (DE-627)NLM369909380 | ||
| 035 | |a (NLM)38501295 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Yan, Yi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Influencing factors of futile recanalization after endovascular intervention in patients with acute basilar artery occlusion |
| 246 | 3 | 3 | |a 急性基底动脉闭塞血管内治疗后发生无效再通的影响因素 |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 19.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a OBJECTIVES: To explore the influence factors for futile recanalization following endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO) | ||
| 520 | |a METHODS: Clinical data of patients with acute BAO, who underwent endovascular treatment within 24 h of onset from January 2017 to November 2022, were retrospectively analyzed. The futile recanalization was defined as modified Thrombolysis in Cerebral Infarction (mTICI)≥2b or 3 after successful reperfusion, but the modified Rankin Scale score >2 at 90d after EVT. Binary logistic regression model was used to analyze the influencing factors of futile recanalization | ||
| 520 | |a RESULTS: A total of 471 BAO patients with a median age of 68 (57-74) years were included and 68.9% were males, among whom 298 (63.27%) experienced futile recanalization. Multivariate analysis revealed that concomitant atrial fibrillation (OR=0.456, 95%CI: 0.287-0.737, P<0.01), bridging thrombolysis (OR=0.640, 95%CI: 0.416-0.985, P<0.05), achieving mTICI grade 3 (OR=0.554, 95%CI: 0.334-0.918, P<0.05), arterial occlusive lesion (AOL) grade 3 (OR=0.521, 95%CI: 0.326-0.834, P<0.01), and early postoperative statin therapy (OR=0.509, 95%CI: 0.273-0.948, P<0.05) were protective factors for futile recanalization after EVT in acute BAO patients; while high baseline National Institutes of Health Stroke Scale (NIHSS) score (OR=1.068, 95%CI: 1.049-1.087, P<0.01), coexisting hypertension (OR=1.571, 95%CI: 1.017-2.427, P<0.05), multiple retrieval attempts (OR=1.237, 95%CI: 1.029-1.488, P<0.05) and postoperative hemorrhagic transformation (OR=8.497, 95%CI: 2.879-25.076, P<0.01) were risk factors. For TOAST classification, cardiogenic embolism (OR=0.321, 95% CI: 0.193-0.534, P<0.01) and other types (OR=0.499, 95% CI: 0.260-0.961, P<0.05) were also an independent risk factors for futile recanalization after EVT in acute BAO | ||
| 520 | |a CONCLUSIONS: The incidence of futile recanalization after EVT in patients with acute BAO is high. Bridging venous thrombolysis before operation and an early postoperative statin therapy may reduce the incidence of futile recanalization | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Basilar artery | |
| 650 | 4 | |a Cerebral infarction | |
| 650 | 4 | |a Endovascular treatment | |
| 650 | 4 | |a Recanalization | |
| 700 | 1 | |a Zhang, Kemeng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Wansi |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Shenqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Jianhua |e verfasserin |4 aut | |
| 700 | 1 | |a Lou, Min |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences |d 2002 |g (2024) vom: 18. März, Seite 1-10 |w (DE-627)NLM123207037 |x 1008-9292 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:18 |g month:03 |g pages:1-10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3724/zdxbyxb-2023-0425 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 18 |c 03 |h 1-10 | ||