Desulfurative Functionalization of β-Acyl Allylic Sulfides with N-H Free Indoles Highly Regioselective at C3 and N1 Positions : Rapid Access to α-Branched Enones
A regiodivergent allylation of 1H-indoles highly selectively at the C3 and N1 positions with β-acyl allylic sulfides through desulfurative C-C/C-N bond-forming reactions has been developed under mild conditions. Notably, the remarkable site-selective switch can be achieved by a delicate choice of solvents and bases. This cost-efficient method displays a broad substrate scope, good functional compatibility, and excellent site-selectivity, thus offering a divergent synthesis of indole substituted α-branched enones, which possess diverse potential opportunities for further applications and derivatization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
The Journal of organic chemistry - 89(2024), 7 vom: 05. Apr., Seite 5200-5206 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dang, Qin-Qin [VerfasserIn] |
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| Anmerkungen: |
Date Revised 05.04.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.joc.4c00205 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369899989 |
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| 245 | 1 | 0 | |a Desulfurative Functionalization of β-Acyl Allylic Sulfides with N-H Free Indoles Highly Regioselective at C3 and N1 Positions |b Rapid Access to α-Branched Enones |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A regiodivergent allylation of 1H-indoles highly selectively at the C3 and N1 positions with β-acyl allylic sulfides through desulfurative C-C/C-N bond-forming reactions has been developed under mild conditions. Notably, the remarkable site-selective switch can be achieved by a delicate choice of solvents and bases. This cost-efficient method displays a broad substrate scope, good functional compatibility, and excellent site-selectivity, thus offering a divergent synthesis of indole substituted α-branched enones, which possess diverse potential opportunities for further applications and derivatization | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Liu, Xue-Ni |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Zhen-Kang |e verfasserin |4 aut | |
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