Oxidative Stress and Migraine
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
The pathogenesis of migraine is not completely understood, but inflammation and oxidative stress seem to be involved, according to data from an experimental model of the disease. This narrative review summarizes data from studies on oxidative stress markers in migraine patients, case-control association studies on the possible association of candidate genes related to oxidative stress with the risk for migraine, studies showing the presence of oxidative stress in experimental models of migraine, and studies on the efficacy of antioxidant drugs in migraine therapy. Many studies have addressed the value of concentrations of prooxidant and antioxidant substances or the activity of antioxidant enzymes in different tissues (mainly in serum/plasma or in blood cells) as possible biomarkers for migraine, being thiobarbituric acid (TBA) reactive substances (TBARS) such as malonyl dialdehyde acid (MDA) and 4-hydroxynonenal, and nitric oxide (this at least during migraine attacks in patients with migraine with aura (MWA) the most reliable. In addition, the possible usefulness of antioxidant treatment is not well established, although preliminary short-term studies suggest a beneficial action of some of them such as Coenzyme Q10 and riboflavin. Both topics require further prospective, multicenter studies with a long-term follow-up period involving a large number of migraine patients and controls.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
---|---|
Enthalten in: |
Molecular neurobiology - (2024) vom: 18. März |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Jiménez-Jiménez, Félix Javier [VerfasserIn] |
---|
Links: |
---|
Themen: |
Animal models |
---|
Anmerkungen: |
Date Revised 19.03.2024 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.1007/s12035-024-04114-7 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369895517 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM369895517 | ||
003 | DE-627 | ||
005 | 20240319233545.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240319s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s12035-024-04114-7 |2 doi | |
028 | 5 | 2 | |a pubmed24n1336.xml |
035 | |a (DE-627)NLM369895517 | ||
035 | |a (NLM)38499906 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Jiménez-Jiménez, Félix Javier |e verfasserin |4 aut | |
245 | 1 | 0 | |a Oxidative Stress and Migraine |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 19.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
520 | |a The pathogenesis of migraine is not completely understood, but inflammation and oxidative stress seem to be involved, according to data from an experimental model of the disease. This narrative review summarizes data from studies on oxidative stress markers in migraine patients, case-control association studies on the possible association of candidate genes related to oxidative stress with the risk for migraine, studies showing the presence of oxidative stress in experimental models of migraine, and studies on the efficacy of antioxidant drugs in migraine therapy. Many studies have addressed the value of concentrations of prooxidant and antioxidant substances or the activity of antioxidant enzymes in different tissues (mainly in serum/plasma or in blood cells) as possible biomarkers for migraine, being thiobarbituric acid (TBA) reactive substances (TBARS) such as malonyl dialdehyde acid (MDA) and 4-hydroxynonenal, and nitric oxide (this at least during migraine attacks in patients with migraine with aura (MWA) the most reliable. In addition, the possible usefulness of antioxidant treatment is not well established, although preliminary short-term studies suggest a beneficial action of some of them such as Coenzyme Q10 and riboflavin. Both topics require further prospective, multicenter studies with a long-term follow-up period involving a large number of migraine patients and controls | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Animal models | |
650 | 4 | |a Antioxidants | |
650 | 4 | |a Migraine | |
650 | 4 | |a Oxidative stress | |
650 | 4 | |a Pathogenesis | |
650 | 4 | |a Therapeutics | |
700 | 1 | |a Alonso-Navarro, Hortensia |e verfasserin |4 aut | |
700 | 1 | |a García-Martín, Elena |e verfasserin |4 aut | |
700 | 1 | |a Espada-Rubio, Silvina |e verfasserin |4 aut | |
700 | 1 | |a Agúndez, José A G |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Molecular neurobiology |d 1990 |g (2024) vom: 18. März |w (DE-627)NLM012626961 |x 1559-1182 |7 nnns |
773 | 1 | 8 | |g year:2024 |g day:18 |g month:03 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12035-024-04114-7 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2024 |b 18 |c 03 |