Pectoralis muscle area as a predictor of mortality in patients hospitalized with bronchiectasis exacerbation
S. Karger AG, Basel..
INTRODUCTION: Data on factors related to mortality in patients with bronchiectasis exacerbation are insufficient. Computerized tomography (CT) can measure the pectoralis muscle area (PMA) and is a useful tool to diagnose sarcopenia. This study aimed to evaluate whether PMA can predict mortality in patients with bronchiectasis exacerbation.
METHODS: Patients hospitalized due to bronchiectasis exacerbation at a single center were retrospectively divided into survivors and non-survivors based on 1-year mortality. Thereafter, a comparison of the clinical and radiologic characteristics was conducted between the two groups.
RESULTS: A total of 66 (14%) patients died at 1 year. In the multivariate analysis, age, body mass index (BMI) < 18.4 kg/m2, sex-specific PMA quartile, ≥ 3 exacerbations in the previous year, serum albumin < 3.5 g/dL, cystic bronchiectasis, tuberculosis-destroyed lung, and diabetes mellitus were independent predictors for the 1-year mortality in patients hospitalized with bronchiectasis exacerbation. A lower PMA was associated with a lower overall survival rate in the survival analysis according to sex-specific quartiles of PMA. PMA had the highest area under the curve during assessment of prognostic performance in predicting the 1-year mortality. The lowest sex-specific PMA quartile group exhibited higher disease severity than the highest quartile group.
CONCLUSIONS: CT-derived PMA was an independent predictor of 1-year mortality in patients hospitalized with bronchiectasis exacerbation. Patients with lower PMA exhibited higher disease severity. These findings suggest that PMA might be a useful marker for providing additional information regarding prognosis of patients with bronchiectasis exacerbation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Respiration; international review of thoracic diseases - (2024) vom: 18. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Seo, Hyewon [VerfasserIn] |
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Date Revised 18.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1159/000538091 |
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| PPN (Katalog-ID): |
NLM369886461 |
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| 100 | 1 | |a Seo, Hyewon |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pectoralis muscle area as a predictor of mortality in patients hospitalized with bronchiectasis exacerbation |
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| 500 | |a Date Revised 18.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a S. Karger AG, Basel. | ||
| 520 | |a INTRODUCTION: Data on factors related to mortality in patients with bronchiectasis exacerbation are insufficient. Computerized tomography (CT) can measure the pectoralis muscle area (PMA) and is a useful tool to diagnose sarcopenia. This study aimed to evaluate whether PMA can predict mortality in patients with bronchiectasis exacerbation | ||
| 520 | |a METHODS: Patients hospitalized due to bronchiectasis exacerbation at a single center were retrospectively divided into survivors and non-survivors based on 1-year mortality. Thereafter, a comparison of the clinical and radiologic characteristics was conducted between the two groups | ||
| 520 | |a RESULTS: A total of 66 (14%) patients died at 1 year. In the multivariate analysis, age, body mass index (BMI) < 18.4 kg/m2, sex-specific PMA quartile, ≥ 3 exacerbations in the previous year, serum albumin < 3.5 g/dL, cystic bronchiectasis, tuberculosis-destroyed lung, and diabetes mellitus were independent predictors for the 1-year mortality in patients hospitalized with bronchiectasis exacerbation. A lower PMA was associated with a lower overall survival rate in the survival analysis according to sex-specific quartiles of PMA. PMA had the highest area under the curve during assessment of prognostic performance in predicting the 1-year mortality. The lowest sex-specific PMA quartile group exhibited higher disease severity than the highest quartile group | ||
| 520 | |a CONCLUSIONS: CT-derived PMA was an independent predictor of 1-year mortality in patients hospitalized with bronchiectasis exacerbation. Patients with lower PMA exhibited higher disease severity. These findings suggest that PMA might be a useful marker for providing additional information regarding prognosis of patients with bronchiectasis exacerbation | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Cha, Seung-Ick |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Jongmin |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Jae-Kwang |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Won Kee |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Ji-Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Sun Ha |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yong Hoon |e verfasserin |4 aut | |
| 700 | 1 | |a Yoo, Seung-Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Shin-Yup |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jaehee |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Chang-Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Jae-Yong |e verfasserin |4 aut | |
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