Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphorylation. It is important to realize the phosphorylation / dephosphorylation differences between a normal and a failing heart. This review focuses on phosphorylation / dephosphorylation changes in the progression of HF and summarizes the effects of phosphorylation / dephosphorylation of LTCC, ER function, and myofilament function in normal conditions and HF based on previous experiments and clinical research. Also, we summarize current therapeutic methods based on abnormal phosphorylation / dephosphorylation and clarify potential therapeutic directions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Heart failure reviews - (2024) vom: 18. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Yan-Bing [VerfasserIn] |
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| Links: |
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| Themen: |
Ca2+ |
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| Anmerkungen: |
Date Revised 18.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s10741-024-10395-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369879481 |
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| 520 | |a © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
| 520 | |a Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphorylation. It is important to realize the phosphorylation / dephosphorylation differences between a normal and a failing heart. This review focuses on phosphorylation / dephosphorylation changes in the progression of HF and summarizes the effects of phosphorylation / dephosphorylation of LTCC, ER function, and myofilament function in normal conditions and HF based on previous experiments and clinical research. Also, we summarize current therapeutic methods based on abnormal phosphorylation / dephosphorylation and clarify potential therapeutic directions | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Ca2+ | |
| 650 | 4 | |a Endoplasmic reticulum | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a L-type calcium channel | |
| 650 | 4 | |a Phosphorylation | |
| 700 | 1 | |a Wang, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yu-Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Xiao-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Yu-Chen |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jing-Sai |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Yi-Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ze-Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Jing-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Zhen-Kang |e verfasserin |4 aut | |
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