Comparative efficacy of interventional therapies and devices for coronary in-stent restenosis : A systematic review and network meta-analysis of randomized controlled trials

© 2024 The Authors..

Background: In-stent restenosis (ISR) has become a significant obstacle to interventional therapy for atherosclerotic cardiovascular disease. The optimal percutaneous coronary intervention (PCI) strategy for patients with coronary ISR remains controversial. This network meta-analysis (NMA) was aimed to compare and estimate the effectiveness of different PCI strategies and commercial devices for the treatment of patients with coronary ISR.

Methods: In present study, we systematically searched PubMed, Embase, Web of Science, and Cochrane Library from database inception to October 20, 2022, to identify randomized controlled trials. We included studies comparing various PCI strategies for the treatment of any type of coronary ISR. The study was registered with PROSPERO, CRD 42022364308.

Results: We included 44 eligible trials including 8479 patients, 39 trials comparing the treatment effects of 10 PCIs, and 5 trials comparing the efficacy between different types of drug-eluting stent (DES) or drug-coated balloon (DCB) devices. Among the PCIs, everolimus-eluting stent was the optimal strategy considering target lesion revascularization (TLR), percent diameter stenosis (%DS), and binary restenosis (BR), and sirolimus-coated balloon was the optimal strategy considering late lumen loss (LLL). In the comparison of commercial devices, the combination strategy excimer laser coronary angioplasty plus SeQuent Please paclitaxel-coated balloon showed promising therapeutic prospects.

Conclusions: DCB and DES remain the preferred treatment strategies for coronary ISR, considering both the primary clinical outcome (TLR) and the angiographic outcomes (LLL, BR, %DS). Personalized combination interventions including DCB or DES hold promise as a novel potential treatment pattern for coronary ISR.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:10

Enthalten in:

Heliyon - 10(2024), 6 vom: 30. März, Seite e27521

Sprache:

Englisch

Beteiligte Personen:

Guo, Shitian [VerfasserIn]
Bi, Chenchen [VerfasserIn]
Wang, Xiang [VerfasserIn]
Lv, Tingting [VerfasserIn]
Zhang, Ziyi [VerfasserIn]
Chen, Xinyi [VerfasserIn]
Yan, Junwei [VerfasserIn]
Mao, Dandan [VerfasserIn]
Huang, Wenxi [VerfasserIn]
Ye, Mengfei [VerfasserIn]
Liu, Zheng [VerfasserIn]
Xie, Xiaojie [VerfasserIn]

Links:

Volltext

Themen:

Coronary in-stent restenosis
Drug-coated balloon
Drug-eluting stent
Journal Article
Network meta-analysis
Percutaneous coronary intervention

Anmerkungen:

Date Revised 19.03.2024

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.1016/j.heliyon.2024.e27521

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM369865545