Newborn screening for G6PD deficiency in HeFei, FuYang and AnQing, China : Prevalence, cut-off value, variant spectrum
2024 Hui Li, Yah Ch'ih, Meiling Li, Yulei Luo, Hao Liu, Junyang Xu, Wangsheng Song, Qingqing Ma, Ziyu Shao, published by CEON/CEES..
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive Mendelian genetic disorder characterized by neonatal jaundice and hemolytic anemia, affecting more than 400 million people worldwide. The purpose of this research was to investigate prevalence rates of G6PD deficiency and to evaluate and establish specific cut-off values in early prediction of G6PD deficiency by regions (HeFei, FuYang, AnQing) on different seasons, as well as to investigate the frequencies of G6PD gene mutations among three regions mentioned above.
Methods: A total of 31,482 neonates (21,402, 7680, and 2340 for HeFei, FuYang, and AnQing cities, respectively) were recruited. Positive subjects were recalled to attend genetic tests for diagnosis. G6PD activity on the Genetic screening processor (GSP analyzer, 2021-0010) was measured following the manufactureržs protocol. The cut-off value was first set to 35 U/dL. The receiver operating characteristics (ROC) curve was employed to assess and compare the efficiency in predicting G6PD deficiency among HeFei, FuYang, and AnQing cities in different seasons.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Journal of medical biochemistry - 43(2024), 1 vom: 25. Jan., Seite 86-96 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Hui [VerfasserIn] |
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| Links: |
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| Themen: |
G6PD deficiency |
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| Anmerkungen: |
Date Revised 19.03.2024 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.5937/jomb0-43078 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369857070 |
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| 520 | |a 2024 Hui Li, Yah Ch'ih, Meiling Li, Yulei Luo, Hao Liu, Junyang Xu, Wangsheng Song, Qingqing Ma, Ziyu Shao, published by CEON/CEES. | ||
| 520 | |a Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive Mendelian genetic disorder characterized by neonatal jaundice and hemolytic anemia, affecting more than 400 million people worldwide. The purpose of this research was to investigate prevalence rates of G6PD deficiency and to evaluate and establish specific cut-off values in early prediction of G6PD deficiency by regions (HeFei, FuYang, AnQing) on different seasons, as well as to investigate the frequencies of G6PD gene mutations among three regions mentioned above | ||
| 520 | |a Methods: A total of 31,482 neonates (21,402, 7680, and 2340 for HeFei, FuYang, and AnQing cities, respectively) were recruited. Positive subjects were recalled to attend genetic tests for diagnosis. G6PD activity on the Genetic screening processor (GSP analyzer, 2021-0010) was measured following the manufactureržs protocol. The cut-off value was first set to 35 U/dL. The receiver operating characteristics (ROC) curve was employed to assess and compare the efficiency in predicting G6PD deficiency among HeFei, FuYang, and AnQing cities in different seasons | ||
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| 650 | 4 | |a newborn screening | |
| 650 | 4 | |a prevalence | |
| 650 | 4 | |a variant spectrum | |
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| 700 | 1 | |a Shao, Ziyu |e verfasserin |4 aut | |
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