Exercise intensity governs tumor control in mice with breast cancer
Copyright © 2024 Gomes-Santos, Kumar, Hausmann, Meyer, Shiferaw, Amoozgar, Jain and Fukumura..
Introduction: Exercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity.
Methods: We subjected mice to low intensity (Li), moderate intensity (Mi) or high intensity (Hi) exercise, or untrained control (Co) groups based on their individual maximal running capacity.
Results: We found that exercise intensity played a critical role in tumor control. Only Mi exercise delayed tumor growth and reduced tumor burden, whereas Li or Hi exercise failed to exert similar antitumor effects. While both Li and Mi exercise normalized the tumor vasculature, only Mi exercise increased tumor infiltrated CD8+ T cells, that also displayed enhanced effector function (higher proliferation and expression of CD69, INFγ, GzmB). Moreover, exercise induced an intensity-dependent mobilization of CD8+ T cells into the bloodstream.
Conclusion: These findings shed light on the intricate relationship between exercise intensity and cancer, with implications for personalized and optimal exercise prescriptions for tumor control.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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Enthalten in: |
Frontiers in immunology - 15(2024) vom: 17., Seite 1339232 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Gomes-Santos, Igor L [VerfasserIn] |
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Links: |
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Themen: |
Breast cancer |
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Anmerkungen: |
Date Completed 19.03.2024 Date Revised 09.04.2024 published: Electronic-eCollection Citation Status MEDLINE |
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doi: |
10.3389/fimmu.2024.1339232 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM369855647 |
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520 | |a Copyright © 2024 Gomes-Santos, Kumar, Hausmann, Meyer, Shiferaw, Amoozgar, Jain and Fukumura. | ||
520 | |a Introduction: Exercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity | ||
520 | |a Methods: We subjected mice to low intensity (Li), moderate intensity (Mi) or high intensity (Hi) exercise, or untrained control (Co) groups based on their individual maximal running capacity | ||
520 | |a Results: We found that exercise intensity played a critical role in tumor control. Only Mi exercise delayed tumor growth and reduced tumor burden, whereas Li or Hi exercise failed to exert similar antitumor effects. While both Li and Mi exercise normalized the tumor vasculature, only Mi exercise increased tumor infiltrated CD8+ T cells, that also displayed enhanced effector function (higher proliferation and expression of CD69, INFγ, GzmB). Moreover, exercise induced an intensity-dependent mobilization of CD8+ T cells into the bloodstream | ||
520 | |a Conclusion: These findings shed light on the intricate relationship between exercise intensity and cancer, with implications for personalized and optimal exercise prescriptions for tumor control | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a CD8+ T cells | |
650 | 4 | |a breast cancer | |
650 | 4 | |a exercise | |
650 | 4 | |a exercise intensity | |
650 | 4 | |a immunity | |
650 | 4 | |a tumor microenvironment | |
700 | 1 | |a Kumar, Ashwin S |e verfasserin |4 aut | |
700 | 1 | |a Hausmann, Franziska |e verfasserin |4 aut | |
700 | 1 | |a Meyer, Max N |e verfasserin |4 aut | |
700 | 1 | |a Shiferaw, Sarah Z |e verfasserin |4 aut | |
700 | 1 | |a Amoozgar, Zohreh |e verfasserin |4 aut | |
700 | 1 | |a Jain, Rakesh K |e verfasserin |4 aut | |
700 | 1 | |a Fukumura, Dai |e verfasserin |4 aut | |
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