Withanone as an Emerging Anticancer Agent and Understanding Its Molecular Mechanisms : Experimental and Computational Evidence
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Despite decades of research and effort, treating cancer is still a challenging task. Current conventional treatments are still unsatisfactory to fully eliminate and prevent re-emergence or relapses, and targeted or personalised therapy, which are more effective in managing cancer, may be unattainable or inaccessible for some. In the past, research in natural products have yielded some of the most commonly used cancer treatment drugs known today. Hence it is possible more are awaiting to be discovered. Withanone, a common withanolide found in the Ayurvedic herb Withania somnifera, has been claimed to possess multiple benefits capable of treating cancer. This review focuses on the potential of withanone as a safe cancer treatment drug based on the pharmacokinetic profile and molecular mechanisms of actions of withanone. Through these in silico and in vitro studies discussed in this review, withanone showspotent anticancer activities and interactions with molecular targets involved in cancer progression. Furthermore, some evidences also show the selective killing property of withanone, which highlights the safety and specificity of withanone in targeting cancer cell. By compiling these evidences, this review hopes to spark interest for future research to be conducted in more extensive studies involving withanone to generate more data, especially involving in vivo experiments and toxicity evaluation of withanone.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Current cancer drug targets - (2024) vom: 14. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stephen, Annatasha [VerfasserIn] |
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| Links: |
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| Themen: |
Anticancer agent. |
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| Anmerkungen: |
Date Revised 18.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0115680096290673240223043650 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369846206 |
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| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a Despite decades of research and effort, treating cancer is still a challenging task. Current conventional treatments are still unsatisfactory to fully eliminate and prevent re-emergence or relapses, and targeted or personalised therapy, which are more effective in managing cancer, may be unattainable or inaccessible for some. In the past, research in natural products have yielded some of the most commonly used cancer treatment drugs known today. Hence it is possible more are awaiting to be discovered. Withanone, a common withanolide found in the Ayurvedic herb Withania somnifera, has been claimed to possess multiple benefits capable of treating cancer. This review focuses on the potential of withanone as a safe cancer treatment drug based on the pharmacokinetic profile and molecular mechanisms of actions of withanone. Through these in silico and in vitro studies discussed in this review, withanone showspotent anticancer activities and interactions with molecular targets involved in cancer progression. Furthermore, some evidences also show the selective killing property of withanone, which highlights the safety and specificity of withanone in targeting cancer cell. By compiling these evidences, this review hopes to spark interest for future research to be conducted in more extensive studies involving withanone to generate more data, especially involving in vivo experiments and toxicity evaluation of withanone | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Withania somnifera | |
| 650 | 4 | |a anticancer agent. | |
| 650 | 4 | |a cancer treatment | |
| 650 | 4 | |a molecular mechanisms | |
| 650 | 4 | |a withanone | |
| 700 | 1 | |a Tune, Bernadette Xin Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yuan Seng |e verfasserin |4 aut | |
| 700 | 1 | |a Batumalaie, Kalaivani |e verfasserin |4 aut | |
| 700 | 1 | |a Sekar, Mahendran |e verfasserin |4 aut | |
| 700 | 1 | |a Sarker, Md Moklesur Rahman |e verfasserin |4 aut | |
| 700 | 1 | |a Subramaniyan, Vetriselvan |e verfasserin |4 aut | |
| 700 | 1 | |a Fuloria, Neeraj Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Fuloria, Shivkanya |e verfasserin |4 aut | |
| 700 | 1 | |a Gopinath, Subash C B |e verfasserin |4 aut | |
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