A Case of Relapsed/Refractory CD56-Positive Acute Promyelocytic Leukemia, in Which Complete Molecular Remission Was Achieved Following Combination Therapy with Venetoclax and Azacitidine
An 84-year-old woman was diagnosed as having acute promyelocytic leukemia(APL)in July Year X-3. The test for promyelocytic leukemia- retinoic acid receptor alpha(PML-RARA)mRNA was positive, while that for CD56 was negative. Since her white blood cell( WBC) count was <3,000/μL, with a count of APL cells of <1,000/μL, she was started on monotherapy with all-trans retinoic acid(ATRA). In September Year X-3, complete hematological remission(CHR)was confirmed. she refused to provide consent for receiving consolidation therapy. In February Year X-2, hematological relapse occurred. She was started on re-induction therapy with arsenite(ATO), and in June Year X-2, complete molecular remission(CMR)was achieved. She was started on post-remission therapy with ATO. In August Year X-1, she developed molecular relapse and was started on tamibarotene(Am80). In October Year X-1, hematological relapse was detected, and the test for CD56 was positive. She was started on combined venetoclax(VEN)+azacitidine(AZA)(VEN+AZA). After completion of 1 course of treatment, CMR was achieved, but she developed hematological relapse after 5 courses of treatment. She died of gastrointestinal hemorrhage. This is considered a valuable case for accumulating information on the treatment of CD56-positive APL resistant to ATRA and ATO.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Gan to kagaku ryoho. Cancer & chemotherapy - 51(2024), 3 vom: 23. März, Seite 291-297 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sekiguchi, Yasunobu [VerfasserIn] |
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| Themen: |
5688UTC01R |
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| Anmerkungen: |
Date Completed 19.03.2024 Date Revised 19.03.2024 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369844920 |
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| 100 | 1 | |a Sekiguchi, Yasunobu |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A Case of Relapsed/Refractory CD56-Positive Acute Promyelocytic Leukemia, in Which Complete Molecular Remission Was Achieved Following Combination Therapy with Venetoclax and Azacitidine |
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| 520 | |a An 84-year-old woman was diagnosed as having acute promyelocytic leukemia(APL)in July Year X-3. The test for promyelocytic leukemia- retinoic acid receptor alpha(PML-RARA)mRNA was positive, while that for CD56 was negative. Since her white blood cell( WBC) count was <3,000/μL, with a count of APL cells of <1,000/μL, she was started on monotherapy with all-trans retinoic acid(ATRA). In September Year X-3, complete hematological remission(CHR)was confirmed. she refused to provide consent for receiving consolidation therapy. In February Year X-2, hematological relapse occurred. She was started on re-induction therapy with arsenite(ATO), and in June Year X-2, complete molecular remission(CMR)was achieved. She was started on post-remission therapy with ATO. In August Year X-1, she developed molecular relapse and was started on tamibarotene(Am80). In October Year X-1, hematological relapse was detected, and the test for CD56 was positive. She was started on combined venetoclax(VEN)+azacitidine(AZA)(VEN+AZA). After completion of 1 course of treatment, CMR was achieved, but she developed hematological relapse after 5 courses of treatment. She died of gastrointestinal hemorrhage. This is considered a valuable case for accumulating information on the treatment of CD56-positive APL resistant to ATRA and ATO | ||
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| 700 | 1 | |a Tsutsumi, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Gomyo, Ayumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kudo, Masahisa |e verfasserin |4 aut | |
| 700 | 1 | |a Maseki, Nobuo |e verfasserin |4 aut | |
| 700 | 1 | |a Iizaki, Yoshie |e verfasserin |4 aut | |
| 700 | 1 | |a Kawamura, Machiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Kazuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Nitta, Hideaki |e verfasserin |4 aut | |
| 700 | 1 | |a Noguchi, Masaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Wakita, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaguchi, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Hirofumi |e verfasserin |4 aut | |
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