Metabolic disruptions and impaired reproductive fitness in wild-caught freshwater turtles (Emydura macquarii macquarii) exposed to elevated per- and polyfluoroalkyl substances (PFAS)
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
Per- and poly-fluoroalkyl substances (PFAS) pose a threat to organisms and ecosystems due to their persistent nature. Ecotoxicology endpoints used in regulatory guidelines may not reflect multiple, low-level but persistent stressors. This study examines the biological effects of PFAS on Eastern short-necked turtles in Queensland, Australia. In this study, blood samples were collected and analysed for PFAS, hormone levels, and functional omics endpoints. High levels of PFAS were found in turtles at the impacted site, with PFOS being the dominant constituent. The PFAS profiles of males and females differed, with males having higher PFAS concentrations. Hormone concentrations differed between impacted and reference sites in male turtles, with elevated testosterone and corticosterone indicative of stress. Further, energy utilisation, nucleotide synthesis, nitrogen metabolism, and amino acid synthesis were altered in both male and female turtles from PFAS-impacted sites. Both sexes show similar metabolic responses to environmental stressors from the PFAS-contaminated site, which may adversely affect their reproductive fitness. Purine metabolism, caffeine metabolism, and ferroptosis pathway changes in turtles can cause gout, cell death, and overall health problems. Further, the study showed that prolonged exposure to elevated PFAS levels in the wild could compromise turtle reproductive fitness by disrupting reproductive steroids and metabolic pathways.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:926 |
|---|---|
| Enthalten in: |
The Science of the total environment - 926(2024) vom: 20. Apr., Seite 171743 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Beale, David J [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Alkanesulfonic Acids |
|---|
| Anmerkungen: |
Date Completed 17.04.2024 Date Revised 17.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.scitotenv.2024.171743 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369837037 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369837037 | ||
| 003 | DE-627 | ||
| 005 | 20240417232650.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240318s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.scitotenv.2024.171743 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1378.xml |
| 035 | |a (DE-627)NLM369837037 | ||
| 035 | |a (NLM)38494020 | ||
| 035 | |a (PII)S0048-9697(24)01886-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Beale, David J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Metabolic disruptions and impaired reproductive fitness in wild-caught freshwater turtles (Emydura macquarii macquarii) exposed to elevated per- and polyfluoroalkyl substances (PFAS) |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.04.2024 | ||
| 500 | |a Date Revised 17.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Per- and poly-fluoroalkyl substances (PFAS) pose a threat to organisms and ecosystems due to their persistent nature. Ecotoxicology endpoints used in regulatory guidelines may not reflect multiple, low-level but persistent stressors. This study examines the biological effects of PFAS on Eastern short-necked turtles in Queensland, Australia. In this study, blood samples were collected and analysed for PFAS, hormone levels, and functional omics endpoints. High levels of PFAS were found in turtles at the impacted site, with PFOS being the dominant constituent. The PFAS profiles of males and females differed, with males having higher PFAS concentrations. Hormone concentrations differed between impacted and reference sites in male turtles, with elevated testosterone and corticosterone indicative of stress. Further, energy utilisation, nucleotide synthesis, nitrogen metabolism, and amino acid synthesis were altered in both male and female turtles from PFAS-impacted sites. Both sexes show similar metabolic responses to environmental stressors from the PFAS-contaminated site, which may adversely affect their reproductive fitness. Purine metabolism, caffeine metabolism, and ferroptosis pathway changes in turtles can cause gout, cell death, and overall health problems. Further, the study showed that prolonged exposure to elevated PFAS levels in the wild could compromise turtle reproductive fitness by disrupting reproductive steroids and metabolic pathways | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biomonitoring | |
| 650 | 4 | |a Hormone disruption | |
| 650 | 4 | |a Metabolomics | |
| 650 | 4 | |a Omics-based ecosurveillance | |
| 650 | 4 | |a PFAS | |
| 650 | 4 | |a Wildlife | |
| 650 | 7 | |a Hormones |2 NLM | |
| 650 | 7 | |a Fluorocarbons |2 NLM | |
| 650 | 7 | |a Alkanesulfonic Acids |2 NLM | |
| 650 | 7 | |a Environmental Pollutants |2 NLM | |
| 700 | 1 | |a Nguyen, Thao V |e verfasserin |4 aut | |
| 700 | 1 | |a Bose, Utpal |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Rohan |e verfasserin |4 aut | |
| 700 | 1 | |a Nelis, Joost Laurus Dinant |e verfasserin |4 aut | |
| 700 | 1 | |a Stockwell, Sally |e verfasserin |4 aut | |
| 700 | 1 | |a Broadbent, James A |e verfasserin |4 aut | |
| 700 | 1 | |a Nilsson, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Rane, Rahul |e verfasserin |4 aut | |
| 700 | 1 | |a Court, Leon |e verfasserin |4 aut | |
| 700 | 1 | |a Lettoof, Damian C |e verfasserin |4 aut | |
| 700 | 1 | |a Pandey, Gunjan |e verfasserin |4 aut | |
| 700 | 1 | |a Walsh, Thomas K |e verfasserin |4 aut | |
| 700 | 1 | |a Shaw, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Llinas, Josh |e verfasserin |4 aut | |
| 700 | 1 | |a Limpus, Duncan |e verfasserin |4 aut | |
| 700 | 1 | |a Limpus, Colin |e verfasserin |4 aut | |
| 700 | 1 | |a Braun, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Baddiley, Brenda |e verfasserin |4 aut | |
| 700 | 1 | |a Vardy, Suzanne |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Science of the total environment |d 1972 |g 926(2024) vom: 20. Apr., Seite 171743 |w (DE-627)NLM000215562 |x 1879-1026 |7 nnns |
| 773 | 1 | 8 | |g volume:926 |g year:2024 |g day:20 |g month:04 |g pages:171743 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.scitotenv.2024.171743 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 926 |j 2024 |b 20 |c 04 |h 171743 | ||