Selenium levels in colorectal cancer : A systematic review and meta-analysis of serum, plasma, and colorectal specimens
Copyright © 2024 Elsevier GmbH. All rights reserved..
BACKGROUND: Colorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially protective effect of selenium (Se), but the reports are inconsistent. The objective of the study was to examine the evidence for relation between serum/tissue Se status and CRC.
METHOD AND MATERIALS: In this Systematic Review and Meta-Analysis, we searched Cochrane Library, EBSCOhost, EMBASE, ProQuest, PubMed/MEDLINE, Scopus, and Web of Science for studies reporting serum/plasma/whole blood/tissue Se concentrations in CRC patients and controls for articles published till August 2023. Meta-analysis was performed, and study quality, heterogeneity, and small study effects were assessed. Based on a random effects model, summary mean differences in serum levels of Se between CRC patients and healthy controls, and Se levels between malignant and matched non-malignant tissue specimens were assessed.
RESULTS: After initial screening, a total of 24 studies (18 serum and 6 tissue studies) with a pooled total of 2640 participants were included in the meta-analysis. CRC patients had significantly lower serum Se levels than healthy controls, being the difference between the two equal to 3.73 µg/dl (95% CI: 6.85-0.61). However, the heterogeneity was very high, I2= 99% (p < 0.01). Our meta-analysis showed higher Se levels in CRC cancerous specimens than in matched healthy colon tissue: the increase was equal to 0.07 µg/g wet tissue weight (95% CI: 0.06-0.09; p= 0.02).
CONCLUSIONS: CRC patients have lower serum and higher colon cancerous tissue Se levels. Some factors, such as Se levels in different tumor grades of CRC need to be further considered for a more conclusive association between Se levels and risk of CRC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:84 |
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| Enthalten in: |
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) - 84(2024) vom: 12. März, Seite 127429 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pal, Amit [VerfasserIn] |
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| Links: |
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| Themen: |
Colorectal cancer |
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| Anmerkungen: |
Date Revised 17.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jtemb.2024.127429 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369833503 |
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| 100 | 1 | |a Pal, Amit |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Selenium levels in colorectal cancer |b A systematic review and meta-analysis of serum, plasma, and colorectal specimens |
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| 520 | |a Copyright © 2024 Elsevier GmbH. All rights reserved. | ||
| 520 | |a BACKGROUND: Colorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially protective effect of selenium (Se), but the reports are inconsistent. The objective of the study was to examine the evidence for relation between serum/tissue Se status and CRC | ||
| 520 | |a METHOD AND MATERIALS: In this Systematic Review and Meta-Analysis, we searched Cochrane Library, EBSCOhost, EMBASE, ProQuest, PubMed/MEDLINE, Scopus, and Web of Science for studies reporting serum/plasma/whole blood/tissue Se concentrations in CRC patients and controls for articles published till August 2023. Meta-analysis was performed, and study quality, heterogeneity, and small study effects were assessed. Based on a random effects model, summary mean differences in serum levels of Se between CRC patients and healthy controls, and Se levels between malignant and matched non-malignant tissue specimens were assessed | ||
| 520 | |a RESULTS: After initial screening, a total of 24 studies (18 serum and 6 tissue studies) with a pooled total of 2640 participants were included in the meta-analysis. CRC patients had significantly lower serum Se levels than healthy controls, being the difference between the two equal to 3.73 µg/dl (95% CI: 6.85-0.61). However, the heterogeneity was very high, I2= 99% (p < 0.01). Our meta-analysis showed higher Se levels in CRC cancerous specimens than in matched healthy colon tissue: the increase was equal to 0.07 µg/g wet tissue weight (95% CI: 0.06-0.09; p= 0.02) | ||
| 520 | |a CONCLUSIONS: CRC patients have lower serum and higher colon cancerous tissue Se levels. Some factors, such as Se levels in different tumor grades of CRC need to be further considered for a more conclusive association between Se levels and risk of CRC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Selenium | |
| 650 | 4 | |a Systematic Reviews and Meta-analysis | |
| 700 | 1 | |a Dhar, Aninda |e verfasserin |4 aut | |
| 700 | 1 | |a Shamim, Muhammad Aaqib |e verfasserin |4 aut | |
| 700 | 1 | |a Rani, Isha |e verfasserin |4 aut | |
| 700 | 1 | |a Negi, Ram Rattan |e verfasserin |4 aut | |
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| 700 | 1 | |a Chatterjee, Namrata |e verfasserin |4 aut | |
| 700 | 1 | |a Goyal, Anmol |e verfasserin |4 aut | |
| 700 | 1 | |a Sadashiv |e verfasserin |4 aut | |
| 700 | 1 | |a Kaur, Bandhan |e verfasserin |4 aut | |
| 700 | 1 | |a Tondolo, Vincenzo |e verfasserin |4 aut | |
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| 700 | 1 | |a Squitti, Rosanna |e verfasserin |4 aut | |
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