Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation´s clinical response in schizophrenia - results from a secondary analysis
Background: The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject´s sex critically influences rTMS´ treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ data is scarce.Methods: Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we assessed the impact of sex on rTMS´ clinical response rate from screening up to 105 days after intervention among SCZ patients. The impact of resting motor threshold (RMT) on response rates was also assessed.Results: 157 patients received either active or sham rTMS treatment. No significant group differences were observed. Linear mixed model showed no effects on response rates (all p > 0.519). Apart from a significant sex*time interaction for the positive subscale of the positive and negative syndrome scale (PANSS) scores (p = 0.032), no other significant effects of sex on continuous PANSS scores were observed. RMT had no effect on response rate.Conclusion: In the largest rTMS trial on the treatment of SCZ negative symptoms we did not observe any significant effect of sex on treatment outcomes. Better assessments of sex-related differences could improve treatment individualization.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - (2024) vom: 17. März, Seite 1-12 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Campana, Mattia [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 17.03.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1080/15622975.2024.2327028 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369830385 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369830385 | ||
| 003 | DE-627 | ||
| 005 | 20240317233519.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240317s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/15622975.2024.2327028 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1333.xml |
| 035 | |a (DE-627)NLM369830385 | ||
| 035 | |a (NLM)38493362 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Campana, Mattia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation´s clinical response in schizophrenia - results from a secondary analysis |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 17.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Background: The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject´s sex critically influences rTMS´ treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ data is scarce.Methods: Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we assessed the impact of sex on rTMS´ clinical response rate from screening up to 105 days after intervention among SCZ patients. The impact of resting motor threshold (RMT) on response rates was also assessed.Results: 157 patients received either active or sham rTMS treatment. No significant group differences were observed. Linear mixed model showed no effects on response rates (all p > 0.519). Apart from a significant sex*time interaction for the positive subscale of the positive and negative syndrome scale (PANSS) scores (p = 0.032), no other significant effects of sex on continuous PANSS scores were observed. RMT had no effect on response rate.Conclusion: In the largest rTMS trial on the treatment of SCZ negative symptoms we did not observe any significant effect of sex on treatment outcomes. Better assessments of sex-related differences could improve treatment individualization | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a RESIS | |
| 650 | 4 | |a negative symptoms | |
| 650 | 4 | |a rTMS | |
| 650 | 4 | |a schizophrenia | |
| 650 | 4 | |a sex | |
| 700 | 1 | |a Schneider-Axmann, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Wobrock, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Malchow, Berend |e verfasserin |4 aut | |
| 700 | 1 | |a Langguth, Berthold |e verfasserin |4 aut | |
| 700 | 1 | |a Landgrebe, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Eichhammer, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Frank, Elmar |e verfasserin |4 aut | |
| 700 | 1 | |a Cordes, Joachim |e verfasserin |4 aut | |
| 700 | 1 | |a Wölwer, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Gaebel, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Winterer, Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Hajak, Göran |e verfasserin |4 aut | |
| 700 | 1 | |a Ohmann, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Verde, Pablo E |e verfasserin |4 aut | |
| 700 | 1 | |a Rietschel, Marcella |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Raees |e verfasserin |4 aut | |
| 700 | 1 | |a Mortazavi, Matin |e verfasserin |4 aut | |
| 700 | 1 | |a Strube, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Falkai, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Hasan, Alkomiet |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Elias |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry |d 2000 |g (2024) vom: 17. März, Seite 1-12 |w (DE-627)NLM12263182X |x 1814-1412 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:17 |g month:03 |g pages:1-12 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/15622975.2024.2327028 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 17 |c 03 |h 1-12 | ||