Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique
© 2024. The Author(s)..
Routine sampling of pregnant women at first antenatal care (ANC) visits could make Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub-Saharan Africa. We compare the genetic structure of parasite populations sampled from 289 first ANC users and 93 children from the community in Mozambique between 2015 and 2019. Samples are amplicon sequenced targeting 165 microhaplotypes and 15 drug resistance genes. Metrics of genetic diversity and relatedness, as well as the prevalence of drug resistance markers, are consistent between the two populations. In an area targeted for elimination, intra-host genetic diversity declines in both populations (p = 0.002-0.007), while for the ANC population, population genetic diversity is also lower (p = 0.0004), and genetic relatedness between infections is higher (p = 0.002) than control areas, indicating a recent reduction in the parasite population size. These results highlight the added value of genomic surveillance at ANC clinics to inform about changes in transmission beyond epidemiological data.
| Errataetall: | |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
|---|---|
| Enthalten in: |
Nature communications - 15(2024), 1 vom: 16. März, Seite 2402 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Brokhattingen, Nanna [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 18.03.2024 Date Revised 25.03.2024 published: Electronic UpdateOf: Res Sq. 2023 Nov 15;:. - PMID 38014035 Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41467-024-46535-x |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369828445 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369828445 | ||
| 003 | DE-627 | ||
| 005 | 20240325235240.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240317s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-024-46535-x |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1346.xml |
| 035 | |a (DE-627)NLM369828445 | ||
| 035 | |a (NLM)38493162 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Brokhattingen, Nanna |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.03.2024 | ||
| 500 | |a Date Revised 25.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a UpdateOf: Res Sq. 2023 Nov 15;:. - PMID 38014035 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a Routine sampling of pregnant women at first antenatal care (ANC) visits could make Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub-Saharan Africa. We compare the genetic structure of parasite populations sampled from 289 first ANC users and 93 children from the community in Mozambique between 2015 and 2019. Samples are amplicon sequenced targeting 165 microhaplotypes and 15 drug resistance genes. Metrics of genetic diversity and relatedness, as well as the prevalence of drug resistance markers, are consistent between the two populations. In an area targeted for elimination, intra-host genetic diversity declines in both populations (p = 0.002-0.007), while for the ANC population, population genetic diversity is also lower (p = 0.0004), and genetic relatedness between infections is higher (p = 0.002) than control areas, indicating a recent reduction in the parasite population size. These results highlight the added value of genomic surveillance at ANC clinics to inform about changes in transmission beyond epidemiological data | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Matambisso, Glória |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva, Clemente |e verfasserin |4 aut | |
| 700 | 1 | |a Neubauer Vickers, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Pujol, Arnau |e verfasserin |4 aut | |
| 700 | 1 | |a Mbeve, Henriques |e verfasserin |4 aut | |
| 700 | 1 | |a Cisteró, Pau |e verfasserin |4 aut | |
| 700 | 1 | |a Maculuve, Sónia |e verfasserin |4 aut | |
| 700 | 1 | |a Cuna, Boaventura |e verfasserin |4 aut | |
| 700 | 1 | |a Melembe, Cardoso |e verfasserin |4 aut | |
| 700 | 1 | |a Ndimande, Nelo |e verfasserin |4 aut | |
| 700 | 1 | |a Palmer, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a García-Ulloa, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Munguambe, Humberto |e verfasserin |4 aut | |
| 700 | 1 | |a Montaña-Lopez, Júlia |e verfasserin |4 aut | |
| 700 | 1 | |a Nhamussua, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Simone, Wilson |e verfasserin |4 aut | |
| 700 | 1 | |a Chidimatembue, Arlindo |e verfasserin |4 aut | |
| 700 | 1 | |a Galatas, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Guinovart, Caterina |e verfasserin |4 aut | |
| 700 | 1 | |a Rovira-Vallbona, Eduard |e verfasserin |4 aut | |
| 700 | 1 | |a Saúte, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Aide, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Aranda-Díaz, Andrés |e verfasserin |4 aut | |
| 700 | 1 | |a Greenhouse, Bryan |e verfasserin |4 aut | |
| 700 | 1 | |a Macete, Eusébio |e verfasserin |4 aut | |
| 700 | 1 | |a Mayor, Alfredo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature communications |d 2010 |g 15(2024), 1 vom: 16. März, Seite 2402 |w (DE-627)NLM199274525 |x 2041-1723 |7 nnns |
| 773 | 1 | 8 | |g volume:15 |g year:2024 |g number:1 |g day:16 |g month:03 |g pages:2402 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41467-024-46535-x |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 15 |j 2024 |e 1 |b 16 |c 03 |h 2402 | ||