Global tuberculosis disease and infection in systemic lupus erythematosus patients : A systematic review and meta-analysis
BACKGROUND: Tuberculosis (TB) is one of the most common infections among systemic lupus erythematosus (SLE) patients. We aimed to evaluate the global prevalence of TB infection and disease, its type, and medication risk factors in SLE patients.
METHODS: We searched PubMed, Science Direct, EBSCO, and Web of Science databases from inception to April 30, 2023, and included studies assessing TB among SLE patients. We estimated the prevalence of TB disease (including type of TB disease), TB infection, and SLE medication as TB risk factors. Meta-analysis was performed using Stata 14.2 and Review Manager 5.3.
RESULTS: Twenty-seven studies met the eligibility criteria. The global prevalence of TB disease was 4% (95% confidence interval (CI): 3-4%, n = 25) and TB infection was 18% (95% CI: 10-26%, n = 3). The pooled prevalence of pulmonary TB, extrapulmonary TB, and disseminated TB were 2% (95% CI: 2-3%, n = 20), 1% (95% CI: 1-2%, n = 17), and 1% (95% CI: 0-1%, n = 6), respectively. The 1-year cumulative glucocorticoid (GC) dose in SLE patients contracting TB was higher than in those without TB, having a mean difference of 2.56 (95% CI: 0.22-4.91, p < .00001, n = 3). The odd ratio of TB was 2.11 (95% CI: 1.01-4.41, p = .05, n = 3) in SLE patients receiving methylprednisolone (MP) pulse therapy as compared to those without MP pulse therapy. Other immunosuppressive agents were not significantly associated with TB.
CONCLUSION: TB prevalence in SLE was relatively high and associated with GC. Awareness of TB and lowering GC dose are warranted to alleviate the TB burden in SLE.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
---|---|
Enthalten in: |
Lupus - 33(2024), 6 vom: 15. Apr., Seite 555-573 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Darmawan, Guntur [VerfasserIn] |
---|
Links: |
---|
Themen: |
Glucocorticoid |
---|
Anmerkungen: |
Date Completed 15.04.2024 Date Revised 15.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1177/09612033241239504 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369806239 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369806239 | ||
003 | DE-627 | ||
005 | 20240415233434.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240316s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1177/09612033241239504 |2 doi | |
028 | 5 | 2 | |a pubmed24n1376.xml |
035 | |a (DE-627)NLM369806239 | ||
035 | |a (NLM)38490946 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Darmawan, Guntur |e verfasserin |4 aut | |
245 | 1 | 0 | |a Global tuberculosis disease and infection in systemic lupus erythematosus patients |b A systematic review and meta-analysis |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 15.04.2024 | ||
500 | |a Date Revised 15.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a BACKGROUND: Tuberculosis (TB) is one of the most common infections among systemic lupus erythematosus (SLE) patients. We aimed to evaluate the global prevalence of TB infection and disease, its type, and medication risk factors in SLE patients | ||
520 | |a METHODS: We searched PubMed, Science Direct, EBSCO, and Web of Science databases from inception to April 30, 2023, and included studies assessing TB among SLE patients. We estimated the prevalence of TB disease (including type of TB disease), TB infection, and SLE medication as TB risk factors. Meta-analysis was performed using Stata 14.2 and Review Manager 5.3 | ||
520 | |a RESULTS: Twenty-seven studies met the eligibility criteria. The global prevalence of TB disease was 4% (95% confidence interval (CI): 3-4%, n = 25) and TB infection was 18% (95% CI: 10-26%, n = 3). The pooled prevalence of pulmonary TB, extrapulmonary TB, and disseminated TB were 2% (95% CI: 2-3%, n = 20), 1% (95% CI: 1-2%, n = 17), and 1% (95% CI: 0-1%, n = 6), respectively. The 1-year cumulative glucocorticoid (GC) dose in SLE patients contracting TB was higher than in those without TB, having a mean difference of 2.56 (95% CI: 0.22-4.91, p < .00001, n = 3). The odd ratio of TB was 2.11 (95% CI: 1.01-4.41, p = .05, n = 3) in SLE patients receiving methylprednisolone (MP) pulse therapy as compared to those without MP pulse therapy. Other immunosuppressive agents were not significantly associated with TB | ||
520 | |a CONCLUSION: TB prevalence in SLE was relatively high and associated with GC. Awareness of TB and lowering GC dose are warranted to alleviate the TB burden in SLE | ||
650 | 4 | |a Meta-Analysis | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Tuberculosis | |
650 | 4 | |a glucocorticoid | |
650 | 4 | |a meta-analysis | |
650 | 4 | |a systemic lupus erythematosus | |
650 | 7 | |a Glucocorticoids |2 NLM | |
650 | 7 | |a Immunosuppressive Agents |2 NLM | |
700 | 1 | |a Liman, Lie Monica Sherine |e verfasserin |4 aut | |
700 | 1 | |a Wibowo, Suryo Anggoro Kusumo |e verfasserin |4 aut | |
700 | 1 | |a Hamijoyo, Laniyati |e verfasserin |4 aut | |
700 | 1 | |a Apriani, Lika |e verfasserin |4 aut | |
700 | 1 | |a Atik, Nur |e verfasserin |4 aut | |
700 | 1 | |a Alisjahbana, Bachti |e verfasserin |4 aut | |
700 | 1 | |a Sahiratmadja, Edhyana |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Lupus |d 1991 |g 33(2024), 6 vom: 15. Apr., Seite 555-573 |w (DE-627)NLM012651214 |x 1477-0962 |7 nnns |
773 | 1 | 8 | |g volume:33 |g year:2024 |g number:6 |g day:15 |g month:04 |g pages:555-573 |
856 | 4 | 0 | |u http://dx.doi.org/10.1177/09612033241239504 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 33 |j 2024 |e 6 |b 15 |c 04 |h 555-573 |