Rotor-based image-guided therapy of glioblastoma
Copyright © 2024. Published by Elsevier B.V..
Glioblastoma (GBM), deep in the brain, is more challenging to diagnose and treat than other tumors. Such challenges have blocked the development of high-impact therapeutic approaches that combine reliable diagnosis with targeted therapy. Herein, effective cyanine dyes (IRLy) with the near-infrared two region (NIR-II) adsorption and aggregation-induced emission (AIE) have been developed via an "extended conjugation & molecular rotor" strategy for multimodal imaging and phototherapy of deep orthotopic GBM. IRLy was synthesized successfully through a rational molecular rotor modification with stronger penetration, higher signal-to-noise ratio, and a high photothermal conversion efficiency (PCE) up to ∼60%, which can achieve efficient NIR-II photo-response. The multifunctional nanoparticles (Tf-IRLy NPs) were further fabricated to cross the blood-brain barrier (BBB) introducing transferrin (Tf) as a targeting ligand. Tf-IRLy NPs showed high biosafety and good tumor enrichment for GBM in vitro and in vivo, and thus enabled accurate, efficient, and less invasive NIR-II multimodal imaging and photothermal therapy. This versatile Tf-IRLy nanosystem can provide a reference for the efficient, precise and low-invasive multi-synergistic brain targeted photo-theranostics. In addition, the "extended conjugation & molecular rotor" strategy can be used to guide the design of other photothermal agents.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:368 |
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| Enthalten in: |
Journal of controlled release : official journal of the Controlled Release Society - 368(2024) vom: 13. Apr., Seite 650-662 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pan, Zhenxing [VerfasserIn] |
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| Links: |
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| Themen: |
Coloring Agents |
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| Anmerkungen: |
Date Completed 10.04.2024 Date Revised 10.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jconrel.2024.03.020 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Glioblastoma (GBM), deep in the brain, is more challenging to diagnose and treat than other tumors. Such challenges have blocked the development of high-impact therapeutic approaches that combine reliable diagnosis with targeted therapy. Herein, effective cyanine dyes (IRLy) with the near-infrared two region (NIR-II) adsorption and aggregation-induced emission (AIE) have been developed via an "extended conjugation & molecular rotor" strategy for multimodal imaging and phototherapy of deep orthotopic GBM. IRLy was synthesized successfully through a rational molecular rotor modification with stronger penetration, higher signal-to-noise ratio, and a high photothermal conversion efficiency (PCE) up to ∼60%, which can achieve efficient NIR-II photo-response. The multifunctional nanoparticles (Tf-IRLy NPs) were further fabricated to cross the blood-brain barrier (BBB) introducing transferrin (Tf) as a targeting ligand. Tf-IRLy NPs showed high biosafety and good tumor enrichment for GBM in vitro and in vivo, and thus enabled accurate, efficient, and less invasive NIR-II multimodal imaging and photothermal therapy. This versatile Tf-IRLy nanosystem can provide a reference for the efficient, precise and low-invasive multi-synergistic brain targeted photo-theranostics. In addition, the "extended conjugation & molecular rotor" strategy can be used to guide the design of other photothermal agents | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cyanine dye | |
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a Multimodal imaging | |
| 650 | 4 | |a NIR-II | |
| 650 | 4 | |a Photothermal therapy | |
| 650 | 7 | |a Coloring Agents |2 NLM | |
| 700 | 1 | |a Zeng, Yaoxun |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Zhaoyi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yushan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yakun |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Zhenzhen |e verfasserin |4 aut | |
| 700 | 1 | |a Bao, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Jiongpeng |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Guining |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Jiapeng |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Yu-Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Kun |e verfasserin |4 aut | |
| 700 | 1 | |a He, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xujie |e verfasserin |4 aut | |
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