A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy
Copyright © 2023. Published by Elsevier B.V..
Non-invasive therapies such as photodynamic therapy (PDT) and chemodynamic therapy (CDT) have received wide attention due to their low toxicity and side effects, but their efficacy is limited by the tumor microenvironment (TME), and monotherapy cannot achieve satisfactory efficacy. In this work, a multifunctional nanoparticle co-assembled from oleanolic acid (OA), chlorin e6 (Ce6) and hemin was developed. The as-constructed nanoparticle named OCH with diameters of around 130 nm possessed good biostability, pH/GSH dual-responsive drug release properties, and remarkable cellular internalization and tumor accumulation capabilities. OCH exhibited prominent catalytic activities to generate •OH, deplete GSH, and produce O2 to overcome the hypoxia TME, thus potentiating the photodynamic and chemodynamic effect. In addition, OCH can induce the occurrence of ferroptosis in both ferroptosis-sensitive and ferroptosis-resistant cancer cells. The multi-pronged effects of OCH including hypoxia alleviation, GSH depletion, ferroptosis induction, CDT and PDT effects jointly facilitate excellent anticancer effects in vitro and in vivo. Hence, this work will advance the development of safe and effective clinically transformable nanomedicine by employing clinically-applied agents to form drug combinations for efficient multi-pronged combination cancer therapy.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:253 |
---|---|
Enthalten in: |
Journal of photochemistry and photobiology. B, Biology - 253(2024) vom: 26. März, Seite 112886 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Shi, Huifang [VerfasserIn] |
---|
Links: |
---|
Themen: |
BBX060AN9V |
---|
Anmerkungen: |
Date Completed 27.03.2024 Date Revised 27.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.jphotobiol.2024.112886 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369797337 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369797337 | ||
003 | DE-627 | ||
005 | 20240328000210.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240316s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.jphotobiol.2024.112886 |2 doi | |
028 | 5 | 2 | |a pubmed24n1351.xml |
035 | |a (DE-627)NLM369797337 | ||
035 | |a (NLM)38490055 | ||
035 | |a (PII)S1011-1344(24)00046-0 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Shi, Huifang |e verfasserin |4 aut | |
245 | 1 | 2 | |a A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 27.03.2024 | ||
500 | |a Date Revised 27.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
520 | |a Non-invasive therapies such as photodynamic therapy (PDT) and chemodynamic therapy (CDT) have received wide attention due to their low toxicity and side effects, but their efficacy is limited by the tumor microenvironment (TME), and monotherapy cannot achieve satisfactory efficacy. In this work, a multifunctional nanoparticle co-assembled from oleanolic acid (OA), chlorin e6 (Ce6) and hemin was developed. The as-constructed nanoparticle named OCH with diameters of around 130 nm possessed good biostability, pH/GSH dual-responsive drug release properties, and remarkable cellular internalization and tumor accumulation capabilities. OCH exhibited prominent catalytic activities to generate •OH, deplete GSH, and produce O2 to overcome the hypoxia TME, thus potentiating the photodynamic and chemodynamic effect. In addition, OCH can induce the occurrence of ferroptosis in both ferroptosis-sensitive and ferroptosis-resistant cancer cells. The multi-pronged effects of OCH including hypoxia alleviation, GSH depletion, ferroptosis induction, CDT and PDT effects jointly facilitate excellent anticancer effects in vitro and in vivo. Hence, this work will advance the development of safe and effective clinically transformable nanomedicine by employing clinically-applied agents to form drug combinations for efficient multi-pronged combination cancer therapy | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Carrier-free | |
650 | 4 | |a Ferroptosis | |
650 | 4 | |a Synergistic therapy | |
650 | 4 | |a Tri-component | |
650 | 4 | |a Tumor microenvironment | |
650 | 7 | |a Hydrogen Peroxide |2 NLM | |
650 | 7 | |a BBX060AN9V |2 NLM | |
700 | 1 | |a Zheng, Fangying |e verfasserin |4 aut | |
700 | 1 | |a Zheng, Yilin |e verfasserin |4 aut | |
700 | 1 | |a Sun, Xianbin |e verfasserin |4 aut | |
700 | 1 | |a Chen, Haijun |e verfasserin |4 aut | |
700 | 1 | |a Gao, Yu |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of photochemistry and photobiology. B, Biology |d 1990 |g 253(2024) vom: 26. März, Seite 112886 |w (DE-627)NLM013030868 |x 1873-2682 |7 nnns |
773 | 1 | 8 | |g volume:253 |g year:2024 |g day:26 |g month:03 |g pages:112886 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jphotobiol.2024.112886 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 253 |j 2024 |b 26 |c 03 |h 112886 |