Enhanced outcomes in residual or recurrent craniopharyngioma : evaluating combined gamma knife and phosphorus-32 brachytherapy
© 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO)..
BACKGROUND: Managing residual and recurrent craniopharyngioma effectively is crucial for improving patient outcomes. This study evaluates the combined use of gamma knife and phosphorus-32 brachytherapy, offering insights into alternative, less invasive treatment strategies.
METHODS: We conducted a retrospective analysis of 97 patients treated from 2010 to 2016 for residual and recurrent craniopharyngioma using gamma knife and phosphorus-32 brachytherapy. We classified these patients into three groups: superficial solid (Group A), simple cystic (Group B), and mixed cystic-solid (Group C). We assessed the treatment's effectiveness by the tumor control rates and evaluated safety by monitoring vision, endocrine function improvements, and complication rates.
RESULTS: The treatment achieved complete and adequate control rates of 49.5% and 87.6%, respectively. We observed improvements in vision or visual fields in 55.1% of the patients. The morbidity rate was 15.5%. The study found no significant differences in tumor control rates among the various lesion types.
CONCLUSION: The combination of gamma knife and phosphorus-32 brachytherapy presents a viable, minimally invasive alternative for treating residual and recurrent craniopharyngioma. It offers high tumor control and functional improvement rates, suggesting its potential as a preferred strategy in some instances.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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Enthalten in: |
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - (2024) vom: 15. März |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ma, Jie [VerfasserIn] |
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Links: |
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Themen: |
Brachytherapy |
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Anmerkungen: |
Date Revised 15.03.2024 published: Print-Electronic Citation Status Publisher |
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doi: |
10.1007/s12094-024-03435-2 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM369786637 |
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520 | |a © 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO). | ||
520 | |a BACKGROUND: Managing residual and recurrent craniopharyngioma effectively is crucial for improving patient outcomes. This study evaluates the combined use of gamma knife and phosphorus-32 brachytherapy, offering insights into alternative, less invasive treatment strategies | ||
520 | |a METHODS: We conducted a retrospective analysis of 97 patients treated from 2010 to 2016 for residual and recurrent craniopharyngioma using gamma knife and phosphorus-32 brachytherapy. We classified these patients into three groups: superficial solid (Group A), simple cystic (Group B), and mixed cystic-solid (Group C). We assessed the treatment's effectiveness by the tumor control rates and evaluated safety by monitoring vision, endocrine function improvements, and complication rates | ||
520 | |a RESULTS: The treatment achieved complete and adequate control rates of 49.5% and 87.6%, respectively. We observed improvements in vision or visual fields in 55.1% of the patients. The morbidity rate was 15.5%. The study found no significant differences in tumor control rates among the various lesion types | ||
520 | |a CONCLUSION: The combination of gamma knife and phosphorus-32 brachytherapy presents a viable, minimally invasive alternative for treating residual and recurrent craniopharyngioma. It offers high tumor control and functional improvement rates, suggesting its potential as a preferred strategy in some instances | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Brachytherapy | |
650 | 4 | |a Craniopharyngioma | |
650 | 4 | |a Phosphorus-32 | |
650 | 4 | |a Recurrent | |
650 | 4 | |a Residual | |
700 | 1 | |a Chen, Tao |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Jianning |e verfasserin |4 aut | |
700 | 1 | |a Cao, Weidong |e verfasserin |4 aut | |
700 | 1 | |a Gao, Gan |e verfasserin |4 aut | |
700 | 1 | |a Yu, Xinguang |e verfasserin |4 aut | |
700 | 1 | |a Wang, Hongwei |e verfasserin |4 aut | |
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